SynthesisBioMed research international2022
The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis.
Synthesis in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Significance of serum biomarkers in preterm infants screened for retinopathy of prematurity: a systematic review and meta-analysis.Eye (London, England) · 2025Pooled it
- Neutrophil to lymphocyte ratio in urolithiasis: a systematic review.BMC urology · 2025Pooled it
- The evaluation of hemogram-related systemic inflammatory markers in pterygium recurrence.BMC ophthalmology · 2026Article
- Prediction of primary glaucoma: development and validation of multiple machine learning models.Scientific reports · 2026Article
- The Relationship Between Composite Inflammatory Indices and Dry Eye in Hashimoto's Disease-Induced Hypothyroid Patients.Biomedicines · 2025Article
- Hematological inflammation biomarkers in patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.International journal of ophthalmology · 2025Article
- Clinical Characteristics and Treatment Outcomes of Pediatric Fungal Keratitis.Infection and drug resistance · 2025Article
- Serologic parameters in young patients with retinal vein occlusion treated with anti-vascular endothelial growth factor.International journal of ophthalmology · 2025Article
- New Biomarkers for Patients With Fungal Keratitis From Blood Routine Examination: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio.Journal of ophthalmology · 2025Article
- Serum inflammation biomarkers level in cystoid and diffuse diabetic macular edema.International ophthalmology · 2024Article
- Evaluation of pseudoexfoliation syndrome patients with systemic immune indexes.BMC ophthalmology · 2024Article
- Hematologic Inflammation Indices for Differentiating between Brucella, Pyogenic, and Tuberculous Spondylodiscitis.Biomedicines · 2024Article
- Complete Blood Cell Count-Derived Inflammation Biomarkers and the Need for Laser Capsulotomy Due to Posterior Capsule Opacification Following Cataract Surgery.Journal of inflammation research · 2024Article
- Prevalence and risk factors of keratoconus (including oxidative stress biomarkers) in a cohort study of Shiraz university of medical science employees in Iran.BMC ophthalmology · 2023Article
- Is Erythrocyte Sedimentation Rate Necessary for the Initial Diagnosis of Giant Cell Arteritis?Life (Basel, Switzerland) · 2023Article
- Blood cell traits and risk of glaucoma: A two-sample mendelian randomization study.Frontiers in genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neutrophil to lymphocyte ratio (NLR) reflects a dynamic relationship between the innate (neutrophils) and adaptive (lymphocytes) cellular immune response. This systematic review and meta-analysis was conducted to critically evaluate the literature regarding the use of the NLR as a reliable means to detect several ocular disorders. Our study was registered with the PROSPERO (ID: CRD42022314850). Three databases, including PubMed, Embase, Scopus, and the Web of Science, were searched on September 9, 2022, with no restrictions on the article's language. Finally, 32 articles were recognized as eligible for our meta-analysis. We found that patients with eye diseases had significantly elevated levels of NLR in comparison to healthy controls (SMD =0.53, 95% CI =0.35-0.71,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.