ArticleeNeurologicalSci2022
Aseptic meningitis in Kikuchi-Fujimoto Disease - Rare manifestation of a rare disease.
Article in eNeurologicalSci, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Histiocytic necrotizing lymphadenitis with central nervous system involvement in children: An analysis of clinical features.Pakistan journal of medical sciences · 2026Article
- Kikuchi-Fujimoto Disease Presenting With Complex Neurological Manifestations: A Case Report.Case reports in neurological medicine · 2026Article
- A Kikuchi-Fujimoto syndrome in the pocket of a non-Hodgkin lymphoma: case report with a mini-review of the literature.Annals of medicine and surgery (2012) · 2025Article
- Kikuchi-Fujimoto disease concurrent with aseptic meningitis or encephalitis in children: a case-control study.BMC pediatrics · 2025Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kikuchi-Fujimoto Disease (KFD) is a rare disease marked by necrotizing lymphadenitis, often presenting as unilateral cervical lymphadenopathy, along with various extranodal manifestations such as fever, skin rash, hepatosplenomegaly, and arthritis, etc. KFD is thought to be secondary to either a viral infection or an autoimmune process, however, evidence in favor of both models is scarce and non-definitive. We report a case of a young female who presented with persistent high-grade fever, bilateral cervical and axillary lymphadenopathy, and leukopenia. Excisional biopsy of affected lymph nodes revealed well-circumscribed foci of necrosis with karyorrhectic debris and scattered fibrin deposits characteristic of KFD. The patient was promptly initiated on non-steroidal anti-inflammatory drugs (NSAIDs), however, despite an early improvement in symptoms, the patient soon developed aseptic meningitis, a rare neurological complication of KFD. Intravenous followed by oral corticosteroid therapy reported a good prognosis, with no observable residual neurological deficits. Knowledge of the disease and its complications significantly helped in the avoidance of unnecessary investigations and a delay in treatment.
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Registered trials
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