Evidence map›Paper›PMID 36281303›Full record

ArticleACS bio & med chem Au2022

In Vitro Demonstration of Human Lipoyl Synthase Catalytic Activity in the Presence of NFU1.

Douglas M Warui, Debangsu Sil, Kyung-Hoon Lee, Syam Sundar Neti, Olga A Esakova, Hayley L Knox, Carsten Krebs, Squire J Booker

Open access · goldAbstract read
In one paragraph

Article in ACS bio & med chem Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Emerging roles of glutaredoxins in plant metabolism.Journal of experimental botany · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Lipoic acid attachment to proteins: stimulating new developments.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Douglas M WaruiDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID https://orcid.org/0000-0001-8950-9433
Debangsu SilDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID https://orcid.org/0000-0002-0718-3925
Kyung-Hoon LeeDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Syam Sundar NetiDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Olga A EsakovaDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID https://orcid.org/0000-0001-8377-8368
Hayley L KnoxDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Carsten KrebsDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID https://orcid.org/0000-0002-3302-7053
Squire J BookerDepartment of Chemistry and Biochemistry and Molecular Biology and the Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID https://orcid.org/0000-0002-7211-5937
Pennsylvania State University · US

Funding

Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
Radical Mechanisms of Iron-Sulfur ProteinsR35GM122595 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SQUIRE J. BOOKER · 2017 to 2026
$3.4M
NIGMS NIH HHS R35 GM122595NIGMS NIH HHS R35 GM127079
6 · The paper itself

Abstract

Lipoyl synthase (LS) catalyzes the last step in the biosynthesis of the lipoyl cofactor, which is the attachment of sulfur atoms at C6 and C8 of an

Identifiers

PMID36281303
PMCPMC9585516
OpenAlexW4282841593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.