Evidence map›Paper›PMID 36281065›Full record

ArticleJournal of dental research2023

TRAF3IP2-IL-17 Axis Strengthens the Gingival Defense against Pathogens.

J Zhang, L Sun, M H H Withanage, S M Ganesan, M A Williamson, J T Marchesan, Y Jiao, F R Teles, N Yu, Y Liu and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. IL-17: Balancing Protective Immunity and Pathogenesis.Journal of immunology research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

J ZhangIowa Institute of Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA, USA.
L SunDepartment of Microbiology & Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
M H H WithanageDivision of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City, IA, USA.
S M GanesanIowa Institute of Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA, USA.
M A WilliamsonIowa Institute of Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA, USA.
J T MarchesanDepartment of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0610-3193
Y JiaoDepartment of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
F R TelesDepartment of Basic & Translational Sciences, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
N YuThe Forsyth Institute, Cambridge, MA, USA.
Y LiuDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
D WuDepartment of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
K L MossDepartment of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
A K MangalamDepartment of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA.
E ZengDivision of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City, IA, USA.
Y L LeiDepartment of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Harbor, MI, USA.
S ZhangIowa Institute of Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA, USA.
University of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of Michigan · USUniversity of Pennsylvania · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Restoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3M
Robust Immuno-prevention Strategies for High-Risk Oral Epithelial DysplasiaU01DE029255 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRENNER, JOHN CHADWICK, LEI, YU LEO · 2019 to 2021
$4.2M
Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7M
New Engineering Strategy for Harnessing Immune System against Head and Neck CancerR01DE030691 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEI, YU LEO, MOON, JAMES J. · 2021 to 2025
$2.9M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
SYSTEMIC EFFECTS OF PERIODONTITISR01DE011551 · NIDCR · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BECK, JAMES D · 1996 to 2002
$1.2M
IFI16 is a Periodontitis Modulating ProteinK01DE027087 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARCHESAN, JULIE TERESA · 2017 to 2022
$833k
NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NIDCR NIH HHS F32 DE026688NIDCR NIH HHS K01 DE027087NIDCR NIH HHS R00 DE027086NIDCR NIH HHS R01 DE011551NIDCR NIH HHS R01 DE021418NIDCR NIH HHS R01 DE026728NIDCR NIH HHS R01 DE030691NIDCR NIH HHS U01 DE029255NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Recent genome-wide association studies have suggested novel risk loci associated with periodontitis, which is initiated by dysbiosis in subgingival plaque and leads to destruction of teeth-supporting structures. One such genetic locus was the tumor necrosis factor receptor-associated factor 3 interacting protein 2 (

Indexed as

Alveolar Bone LossPeriodontitisAdaptor Proteins, Signal TransducingAnimalsGenome-Wide Association StudyGingivaInterleukin-17MiceMice, KnockoutPorphyromonas gingivalisAdaptor Proteins, Signal TransducingInterleukin-17Traf3ip2 protein, mousebone losschemokinescytokinesgenomicsmicrobiomeperiodontitis

Identifiers

PMID36281065
PMCPMC9780753
OpenAlexW4307229611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.