Evidence map›Paper›PMID 36280877›Full record

SynthesisParasites & vectors2022

Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis.

Dhan Bahadur Shrestha, Pravash Budhathoki, Bipana Gurung, Subash Subedi, Shishir Aryal, Anisha Basukala, Barun Aryal, Anurag Adhikari, Ayusha Poudel, Gopal Kumar Yadav and 3 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dhan Bahadur ShresthaDepartment of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.
Pravash BudhathokiDepartment of Internal Medicine, Bronxcare Health System, Bronx, NY, USA.
Bipana GurungChitwan Medical College, Chitwan, Nepal.
Subash SubediChitwan Medical College, Chitwan, Nepal.
Shishir AryalChitwan Medical College, Chitwan, Nepal.
Anisha BasukalaNepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Barun AryalDepartment of Emergency Medicine, Patan Academy of Health Sciences, Lalitpur, Nepal.
Anurag AdhikariDepartment of Emergency Medicine, Nepal National Hospital, Kathmandu, Nepal.
Ayusha PoudelDepartment of Emergency Medicine, Alka Hospital, Kathmandu, Nepal.
Gopal Kumar YadavDepartment of Emergency Medicine, Kalaiya Hospital, Bara, Nepal.
Mtanis KhouryDepartment of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.
Binod RayamajheeSchool of Optometry & Vision Science, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Lok Bahadur ShresthaDepartment of Microbiology & Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, 56700, Nepal. lok.shrestha@bpkihs.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries.

methodsThe PubMed, PubMed Central, Embase and Scopus databases were searched for relevant studies. Statistical analysis on data extracted from the selected studied was conducted using the Comprehensive Meta-Analysis Software (CMA) version 3 software package. Proportions were used to estimate the outcome with a 95% confidence interval (CI).

resultsAcross all studies, among cases of suspected dengue, 30.7% were confirmed dengue cases (proportion: 0.307, 95% CI: 0.277-0.339). The seroprevalence of dengue immunoglobulin (Ig)G, IgM or both (IgM and IgG) antibodies and dengue NS1 antigen was 34.6, 34.2, 29.0 and 24.1%, respectively. Among the different strains of dengue, dengue virus (DENV) strains DENV-1, DENV-2, DENV-3 and DENV-4 accounted for 21.8, 41.2, 14.7 and 6.3% of cases, respectively. The prevalence of dengue fever, dengue hemorrhagic fever and dengue shock syndrome was 80.5, 18.2 and 1.5%, respectively. Fever was a commonly reported symptom, and thrombocytopenia was present in 44.7% of cases. Mortality was reported in 1.9% of dengue cases.

conclusionsDengue is a common health problem in South East Asia with high seroprevalence. DENV-2 was found to be the most common strain causing infection, and most dengue cases were dengue fever. In addition, thrombocytopenia was reported in almost half of the dengue cases.

Indexed as

DengueDengue VirusThrombocytopeniaAntibodies, ViralHumansImmunoglobulin GImmunoglobulin MSeroepidemiologic StudiesAntibodies, ViralImmunoglobulin GImmunoglobulin MDengueDengue feverDengue shock syndromeSAARC region

Identifiers

PMID36280877
PMCPMC9594905

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.