Evidence map›Paper›PMID 36280866›Full record

ReviewVirology journal2022

Narrative review on century of respiratory pandemics from Spanish flu to COVID-19 and impact of nanotechnology on COVID-19 diagnosis and immune system boosting.

Walid F Elkhatib, Shereen S Abdelkareem, Wafaa S Khalaf, Mona I Shahin, Dounia Elfadil, Alaa Alhazmi, Ahmed I El-Batal, Gharieb S El-Sayyad

Open access · goldAbstract readHistorical ArticleReview
In one paragraph

Review in Virology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 4 countries.

Walid F ElkhatibMicrobiology and Immunology Department, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Abbassia, Cairo, 11566, Egypt. walid-elkhatib@pharma.asu.edu.eg.ORCID 0000-0001-5815-3200
Shereen S AbdelkareemDepartment of Alumni, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC), Entertainment Area, Badr City, Cairo, Egypt.
Wafaa S KhalafDepartment of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, 11751, Egypt.
Mona I ShahinZoology Department, Faculty of Tymaa, Tabuk University, Tymaa, 71491, Kingdom of Saudi Arabia.
Dounia ElfadilBiology and Chemistry Department, Hassan II University of Casablanca, Casablanca, Morocco.
Alaa AlhazmiMedical Laboratory Technology Department, Jazan University, Jazan, Saudi Arabia.
Ahmed I El-BatalDrug Microbiology Laboratory, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Gharieb S El-SayyadDepartment of Microbiology and Immunology, Faculty of Pharmacy, Galala University, New Galala City, Suez, Egypt. Gharieb.S.Elsayyad@eaea.org.eg.ORCID 0000-0001-5410-7936
Ain Shams University · EGAl-Azhar University · EGBadr University in Cairo · EGEgyptian Atomic Energy Authority · EGJazan University · SASuez University · EGUniversity of Hassan II Casablanca · MAUniversity of Tabuk · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of the highly lethal severe acute respiratory syndrome-2 (SARS-2) as corona virus 2019 (COVID-19) reminded us of the history of other pandemics that happened in the last century (Spanish flu) and stayed in the current century, which include Severe-Acute-Respiratory-Syndrome (SARS), Middle-East-Respiratory-Syndrome (MERS), Corona Virus 2019 (COVID-19). We review in this report the newest findings and data on the origin of pandemic respiratory viral diseases, reservoirs, and transmission modes. We analyzed viral adaption needed for host switch and determinants of pathogenicity, causative factors of pandemic viruses, and symptoms and clinical manifestations. After that, we concluded the host factors associated with pandemics morbidity and mortality (immune responses and immunopathology, ages, and effect of pandemics on pregnancy). Additionally, we focused on the burdens of COVID-19, non-pharmaceutical interventions (quarantine, mass gatherings, facemasks, and hygiene), and medical interventions (antiviral therapies and vaccines). Finally, we investigated the nanotechnology between COVID-19 analysis and immune system boosting (Nanoparticles (NPs), antimicrobial NPs as antivirals and immune cytokines). This review presents insights about using nanomaterials to treat COVID-19, improve the bioavailability of the abused drugs, diminish their toxicity, and improve their performance.

Indexed as

COVID-19Influenza Pandemic, 1918-1919Middle East Respiratory Syndrome CoronavirusAntiviral AgentsCOVID-19 TestingCytokinesHistory, 20th CenturyHumansImmune SystemNanotechnologyPandemicsAntiviral AgentsCytokinesImmune systemNanotechnologyRespiratory pandemicsSARS-CoV-2Spanish flu

Identifiers

PMID36280866
PMCPMC9589879
OpenAlexW4307379553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.