ArticleBMC medicine2022
Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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Who cites it
136 citing papers in PubMed, 196 citations in OpenAlex.
- Cardiac autonomic neuropathy modified the association between obesity and hypoglycemia in type 2 diabetes.Endocrine · 2024Trial
- Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank.Sexual medicine · 2026Article
- Relationship between cardiometabolic alterations and frailty in Brazilian urban and rural older adults.Journal of diabetes and metabolic disorders · 2026Article
- Outcomes for Frail Dialysis Patients Not Referred for Transplantation: A Cohort Study.Journal of the American Geriatrics Society · 2026Article
- Risk of protein intake deficiency during treatment with GLP-1 and GIP/GLP-1 receptor agonists: considerations for secondary sarcopenia.Advances in therapy · 2026Review
- Regional fat distribution as a novel predictor of fracture risk in inflammatory bowel disease: a DXA-based cohort study.BMJ open gastroenterology · 2026Article
- Body Mass Index and All-Cause, Cancer, and Cardiovascular Mortality in Adults Aged 16-50 Years With and Without Type 2 Diabetes: An Analysis of Primary Care Records in England.Diabetes, obesity & metabolism · 2026Article
- Adipose Reserves and Survival: Protective in Prefrail but Ineffective in Frail Oldest-Old.Journal of cachexia, sarcopenia and muscle · 2026Article
- Preventive Strategies and Determinants of Vaccination Compliance Among Older Adults in Rural Amazonian Communities.Vaccines · 2026Article
- Trajectories of Frailty and Depression and Their Associations with the Risk of Gastrointestinal and Liver Disease: Findings from China Health and Retirement Longitudinal Study and Validation of Survey of Health, Aging and Retirement in Europe.Healthcare (Basel, Switzerland) · 2026Article
- Article
- Association between body roundness index and frailty among middle aged and older adults in China.Scientific reports · 2026Article
- The impact of BMI on mechanical thrombectomy outcomes, insights from a comprehensive stroke center.Neurosurgical review · 2026Article
- Low Body Mass Index Increases Frailty Risk in Old-Old Adults: Findings From a 3-Year Longitudinal Study.Geriatrics & gerontology international · 2026Article
- "Health literacy, health behavior, and demographic determinants of BMI status among pre-older adults: a cross-sectional study".BMC nutrition · 2026Article
- The association of depressive symptoms and dietary inflammatory index with frailty in older adults with diabetes.BMC psychiatry · 2026Article
- Extensive antibiotic use during early life and risk of frailty: a population-based cohort study in the UK biobank.BMC public health · 2026Article
- Age disparity in robotic colorectal surgery: overcoming surgeon hesitancy to improve elderly patient outcomes.Journal of robotic surgery · 2026Article
- Change of frailty index and anthropometric indices in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Rheumatoid arthritis and gout: a rare combination or overlooked coexistence?Arthritis research & therapy · 2026Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundParallel to growth of aging and obese populations, the prevalence of metabolic diseases is rising. How body mass index (BMI) relates to frailty and mortality across frailty levels is controversial. We examined the associations of high BMI with frailty and mortality and explored the effects of percent body fat on these associations.
methodsWe included 29,937 participants aged ≥50 years from the 2001-2006 National Health and Nutrition Examination Survey (NHANES) cohorts (N=6062; 53.7% females) and from wave 1 (2004) of Survey of Health, Ageing and Retirement in Europe (SHARE) (N=23,875; 54% females). BMI levels were categorized as: normal: 18.5-24.9 kg/m
resultsMean age of participants was 63.3±10.2 years for NHANES and 65.0±10.0 years for SHARE. In both cohorts, BMI levels ≥25 kg/m
conclusionsBeing overweight or obese is associated with higher frailty levels. In this study, we found that being overweight is a protective factor of mortality in moderately/severely frail people and obesity grade 1 may be protective for mortality for people with at least a mild level of frailty. In contrast, obesity grades 2 and 3 may be associated with higher mortality risk in non-frail people. The relationship between BMI and frailty is partially explained by body fat.
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