ArticleMicrobiome2022
Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of enrofloxacin and sulfamethoxazole on Haematococcus lacustris.Bioprocess and biosystems engineering · 2026Article
- An Insight into the Effects of Five Antibiotics on Haematococcus lacustris.Current microbiology · 2026Article
- The Metabolites of Secoiridoid Enantiomers and Diastereomers with 9-Carbon Skeleton inCurrent drug metabolism · 2026Article
- Antibiotic: a boon to mankind and doom to the environment - an insight on biological and non-biological degradation processes.Frontiers in microbiology · 2026Review
- Dynamics of archaeal diversity and functionality in the piglet gut microbiome under common antimicrobial treatments.Frontiers in cellular and infection microbiology · 2026Article
- Proteomic and metabolomic responses of priority bacterial pathogens to subinhibitory concentration of antibiotics.npj antimicrobials and resistance · 2025Article
- Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium.Nature communications · 2025Article
- A Globally Distributed Cyanobacterial Nitroreductase Capable of Conferring Biodegradation of Chloramphenicol.Research (Washington, D.C.) · 2025Article
- NIR light-driven nanomotor with cascade photodynamic therapy for MRSA biofilm eradication and diabetic wound healing.Theranostics · 2025Article
- Article
- Microbial degradation of contaminants of emerging concern: metabolic, genetic and omics insights for enhanced bioremediation.Frontiers in bioengineering and biotechnology · 2024Review
- Establishment of microbial model communities capable of removing trace organic chemicals for biotransformation mechanisms research.Microbial cell factories · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a widely used broad-spectrum antibiotic, chloramphenicol is prone to be released into environments, thus resulting in the disturbance of ecosystem stability as well as the emergence of antibiotic resistance genes. Microbes play a vital role in the decomposition of chloramphenicol in the environment, and the biotransformation processes are especially dependent on synergistic interactions and metabolite exchanges among microbes. Herein, the comprehensive chloramphenicol biotransformation pathway, key metabolic enzymes, and interspecies interactions in an activated sludge-enriched consortium were elucidated using integrated multi-omics and cultivation-based approaches.
resultsThe initial biotransformation steps were the oxidization at the C
conclusionThis study provides desirable strain and enzyme resources for enhanced bioremediation of chloramphenicol-contaminated hotspot sites such as pharmaceutical wastewater and livestock and poultry wastewater. The in-depth understanding of the chloramphenicol biotransformation mechanisms and microbial interactions will not only guide the bioremediation of organic pollutants but also provide valuable knowledge for environmental microbiology and biotechnological exploitation. Video Abstract.
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