ArticleNature neuroscience2022
Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- Topographic Mesocortex-Amygdalar Projections Expand the Molecular and Functional Model of the Limbic System.Molecular neurobiology · 2026Article
- Strain-Dependent Network Activity Differences Underlie Social Decision-Making in Male Mice.eNeuro · 2026Article
- Individual differences in prosocial learning are represented in the hippocampal dorsal CA1.Nature neuroscience · 2026Article
- Cooperation: Behavioral manifestations and neural mechanisms.Current opinion in neurobiology · 2026Review
- Neural correlates of adversity-overcoming pup rescue behavior in female mice.Scientific reports · 2026Article
- The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Article
- Empathy and prosocial behavior powered by orexin-driven theta oscillations.Science (New York, N.Y.) · 2026Article
- Prefrontal and Subcortical c-Fos Mapping of Reward Responses across Competitive and Social Contexts.eNeuro · 2025Article
- Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala.Scientific reports · 2025Article
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Article
- Fear Synchrony of Mouse Dyads: Interaction of Sex Composition and Stress.Biological psychiatry global open science · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Prosocial Helping Behavior: Conceptual Issues and Neural Mechanisms.Biological psychiatry · 2025Review
- Steeper social discounting after human basolateral amygdala damage.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Historical loss weakens competitive behavior by remodeling ventral hippocampal dynamics.Cell discovery · 2025Article
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13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that basolateral amygdala (BLA) neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic (PL) region of the prefrontal cortex mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives for decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.