ArticleNature ecology & evolution2022
Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- A Pseudohaploid-Based Imputation Strategy for Interspecific FMolecular ecology · 2026Article
- Evolution of a ZW sex determination system in sticklebacks.Science advances · 2026Article
- Rapid turnover of sex-determining architecture in invasive mussels.bioRxiv : the preprint server for biology · 2026Article
- Whole genome DNA methylation atlas of the scallop Patinopecten yessoensis.Scientific data · 2026Article
- Systematic evaluation of scallop (Argopecten irradians) SoxH reveals its crucial role in spermiogenesis with limited evidence for sex determination.Communications biology · 2026Article
- Glass scallop genome reveals key adaptations to deep-sea environments and ectosymbiosis.Nature communications · 2026Article
- Genome-Wide Characterization of Sex-Linked Regions in the Sangzhi Horned Toad (Boulenophrys sangzhiensis) Reveals Complex Sex Determination Mechanisms.Molecular ecology resources · 2026Article
- Evolutionary dynamics of sex determination in Branchiostoma belcheri driven by repeated transposition of a single novel gene.Nature communications · 2026Article
- ZW and XY Sex Chromosomes Drive Rapid and Distinctive Evolution of Sex-Biased Gene Expression.Molecular ecology · 2025Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Evolutionary Analysis of Sex-Biased Gene Suggests Functional Conservation of Lifespan-Related Genes in Insecta.Biology · 2025Article
- Sharks and rays have the oldest vertebrate sex chromosome with unique sex determination mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes.BMC genomics · 2025Article
- Core histone families of mollusca: systematic identification, evolutionary insights, and functional analysis.BMC genomics · 2025Article
- Simple Transgene Overexpression using Scallop Hemocyte Culture Platform Enables Functional Genetic Research in Molluscs.Marine biotechnology (New York, N.Y.) · 2025Article
- Allelic variation and duplication of the dmrt1 were associated with sex chromosome turnover in three representative Scatophagidae fish species.Communications biology · 2025Article
- Cephalopod sex determination and its ancient evolutionary origin.Current biology : CB · 2025Article
- The genome of Hippophae salicifolia provides new insights into the sexual differentiation of sea buckthorn.GigaScience · 2025Article
- Systematic screening and dynamic profiling of germline regulatory pathways and spermatogonial surface markers in a bivalve mollusc.Computational and structural biotechnology journal · 2025Article
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26 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrary to classic theory prediction, sex-chromosome homomorphy is prevalent in the animal kingdom but it is unclear how ancient homomorphic sex chromosomes avoid chromosome-scale degeneration. Molluscs constitute the second largest, Precambrian-originated animal phylum and have ancient, uncharacterized homomorphic sex chromosomes. Here, we profile eight genomes of the bivalve mollusc family of Pectinidae in a phylogenetic context and show 350 million years sex-chromosome homomorphy, which is the oldest known sex-chromosome homomorphy in the animal kingdom, far exceeding the ages of well-known heteromorphic sex chromosomes such as 130-200 million years in mammals, birds and flies. The long-term undifferentiation of molluscan sex chromosomes is potentially sustained by the unexpected intertwined regulation of reversible sex-biased genes, together with the lack of sexual dimorphism and occasional sex chromosome turnover. The pleiotropic constraint of regulation of reversible sex-biased genes is widely present in ancient homomorphic sex chromosomes and might be resolved in heteromorphic sex chromosomes through gene duplication followed by subfunctionalization. The evolutionary dynamics of sex chromosomes suggest a mechanism for 'inheritance' turnover of sex-determining genes that is mediated by translocation of a sex-determining enhancer. On the basis of these findings, we propose an evolutionary model for the long-term preservation of homomorphic sex chromosomes.
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