ArticleNature biomedical engineering2023
Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing.
Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Volumetric FLASH dosimetryPhysics in medicine and biology · 2026Article
- Pair production tomography enables imaging of MeV-scale gamma-emitting theranostic radionuclides.Research square · 2026Article
- Seeing the invisible: In vivo dosimetry in radiotherapy with radiacoustic IMAGING.Medical physics · 2025Review
- An interface tool to parametrize treatment plans for the TrueBeam radiotherapy system into TOPAS parameter control files for Monte Carlo simulation.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2024Article
- Real-time tracking of the Bragg peak during proton therapy via 3D protoacoustic Imaging in a clinical scenario.Npj imaging · 2024Article
- Lead-Free Halide Perovskites for Direct X-Ray Detectors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Measuring the radiation dose reaching a patient's body is difficult. Here we report a technique for the tomographic reconstruction of the location of photon pairs originating from the annihilation of positron-electron pairs produced by high-energy X-rays travelling through tissue. We used Monte Carlo simulations on pre-recorded data from tissue-mimicking phantoms and from a patient with a brain tumour to show the feasibility of this imaging modality, which we named 'pair-production tomography', for the monitoring of radiotherapy dosing. We simulated three image-reconstruction methods, one applicable to a pencil X-ray beam scanning through a region of interest, and two applicable to the excitation of tissue volumes via broad beams (with temporal resolution sufficient to identify coincident photon pairs via filtered back projection, or with higher temporal resolution sufficient for the estimation of a photon's time-of-flight). In addition to the monitoring of radiotherapy dosing, we show that image contrast resulting from pair-production tomography is highly proportional to the material's atomic number. The technique may thus also allow for element mapping and for soft-tissue differentiation.
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Registered trials
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