Evidence map›Paper›PMID 36280717›Full record

ArticleNature methods2022

Automated synapse-level reconstruction of neural circuits in the larval zebrafish brain.

Fabian Svara, Dominique Förster, Fumi Kubo, Michał Januszewski, Marco Dal Maschio, Philipp J Schubert, Jörgen Kornfeld, Adrian A Wanner, Eva Laurell, Winfried Denk and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 110 citations in OpenAlex.

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  12. A connectomics-driven analysis reveals novel characterization of border regions in mouse visual cortex.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
  13. Article
  14. Review
  15. On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025
    Review
  16. Article
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  19. Article
  20. Eat, flee, freeze: Division of labor in the larval zebrafish visuomotor system.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Fabian SvaraMax Planck Institute for Biological Intelligence, Martinsried, Germany.
Dominique FörsterMax Planck Institute for Biological Intelligence, Martinsried, Germany.ORCID 0000-0002-7821-6755
Fumi KuboMax Planck Institute for Biological Intelligence, Martinsried, Germany.
Michał JanuszewskiGoogle Research, Zürich, Switzerland.ORCID 0000-0002-3480-2744
Marco Dal MaschioMax Planck Institute for Biological Intelligence, Martinsried, Germany.ORCID 0000-0003-0150-6647
Philipp J SchubertMax Planck Institute for Biological Intelligence, Martinsried, Germany.ORCID 0000-0003-1265-3028
Jörgen KornfeldMax Planck Institute for Biological Intelligence, Martinsried, Germany.ORCID 0000-0002-2547-8700
Adrian A WannerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Eva LaurellMax Planck Institute for Biological Intelligence, Martinsried, Germany.
Winfried DenkMax Planck Institute for Biological Intelligence, Martinsried, Germany.
Herwig BaierMax Planck Institute for Biological Intelligence, Martinsried, Germany. herwig.baier@bi.mpg.de.ORCID 0000-0002-7268-0469
Max Planck Institute for Biological IntelligenceBüchi Labortechnik · CHGoogle (Switzerland) · CHMax Planck Institute of Biochemistry · DENational Institute of Genetics · JPPrinceton University · USUniversity of Cologne · DEUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dense reconstruction of synaptic connectivity requires high-resolution electron microscopy images of entire brains and tools to efficiently trace neuronal wires across the volume. To generate such a resource, we sectioned and imaged a larval zebrafish brain by serial block-face electron microscopy at a voxel size of 14 × 14 × 25 nm

Indexed as

SynapsesZebrafishAnimalsBrainLarvaMicroscopy, Electron

Identifiers

PMID36280717
PMCPMC9636024
OpenAlexW4307231400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.