Evidence map›Paper›PMID 36280715›Full record

ArticleNature methods2022

SyConn2: dense synaptic connectivity inference for volume electron microscopy.

Philipp J Schubert, Sven Dorkenwald, Michał Januszewski, Jonathan Klimesch, Fabian Svara, Andrei Mancu, Hashir Ahmad, Michale S Fee, Viren Jain, Joergen Kornfeld

Abstract read
In one paragraph

Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. The songbird basal ganglia connectome.bioRxiv : the preprint server for biology · 2025
    Article
  3. An anatomical substrate of credit assignment in reinforcement learning.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. CAVE: Connectome Annotation Versioning Engine.bioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Philipp J SchubertMax Planck Institute of Neurobiology, Martinsried, Germany.ORCID 0000-0003-1265-3028
Sven DorkenwaldMax Planck Institute of Neurobiology, Martinsried, Germany.
Michał JanuszewskiGoogle Research, Zurich, Switzerland.ORCID 0000-0002-3480-2744
Jonathan KlimeschMax Planck Institute of Neurobiology, Martinsried, Germany.
Fabian SvaraMax Planck Institute for Neurobiology of Behavior - caesar, Bonn, Germany.
Andrei MancuMax Planck Institute of Neurobiology, Martinsried, Germany.ORCID 0000-0002-5096-9835
Hashir AhmadMax Planck Institute of Neurobiology, Martinsried, Germany.ORCID 0000-0002-5970-573X
Michale S FeeDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7539-1745
Viren JainGoogle Research, Mountain View, CA, USA.ORCID 0000-0003-1488-3505
Joergen KornfeldMax Planck Institute of Neurobiology, Martinsried, Germany. joergen.kornfeld@bi.mpg.de.ORCID 0000-0002-2547-8700

Funding

From Electron Microscopy to Neural Circuit Hypotheses: Bridging the GapRF1MH117809 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FEE, MICHALE S · 2018 to 2018
$1.9M
NIMH NIH HHS RF1 MH117809
6 · The paper itself

Abstract

The ability to acquire ever larger datasets of brain tissue using volume electron microscopy leads to an increasing demand for the automated extraction of connectomic information. We introduce SyConn2, an open-source connectome analysis toolkit, which works with both on-site high-performance compute environments and rentable cloud computing clusters. SyConn2 was tested on connectomic datasets with more than 10 million synapses, provides a web-based visualization interface and makes these data amenable to complex anatomical and neuronal connectivity queries.

Indexed as

ConnectomeBrainMicroscopy, ElectronNeuronsSynapses

Identifiers

PMID36280715
PMCPMC9636020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.