Evidence map›Paper›PMID 36280510›Full record

ArticleSurgery2023

Simulated data-driven hospital selection for surgical treatment of well-differentiated thyroid cancer in older adults.

Caitlin B Finn, Chris Wirtalla, Tory Mascuilli, Lauren N Krumeich, Heather Wachtel, Douglas Fraker, Rachel R Kelz

Abstract read
In one paragraph

Article in Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caitlin B FinnDepartment of Surgery, Weill Cornell Medicine, New York, NY; Center for Surgery and Health Economics, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA. Electronic address: Caitlin.Finn@pennmedicine.upenn.edu.
Chris WirtallaCenter for Surgery and Health Economics, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Tory MascuilliCenter for Surgery and Health Economics, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Lauren N KrumeichDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address: https://twitter.com/LaurenNorell.
Heather WachtelDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Douglas FrakerDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Rachel R KelzCenter for Surgery and Health Economics, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address: https://twitter.com/surgeryspice.

Funding

Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
Parathyroid Tumor Clonal Status as a Biomarker in Primary HyperparathyroidismR01CA228399 · NCI · WASHINGTON UNIVERSITY · PI OLSON, JOHN A. · 2019 to 2023
$3.2M
Using Outcomes to Guide Treatment of Surgical EmergenciesR01AG060612 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KELZ, RACHEL · 2019 to 2023
$2.7M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAM AT PENNT32CA251063 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2020 to 2026
$2.6M
NCATS NIH HHS KL2 TR001879NCI NIH HHS R01 CA228399NCI NIH HHS T32 CA251063NIA NIH HHS R01 AG060612
6 · The paper itself

Abstract

backgroundThyroid surgery at high-quality hospitals is associated with fewer complications. We evaluated the impact of referring older adults with thyroid cancer to higher-performing local hospitals.

methodsWe performed a simulation study of Surveillance, Epidemiology, and End Results-Medicare patients, aged ≥66 years, who underwent a thyroidectomy for well-differentiated thyroid cancer (2013-2017). An 80% sample was used to calculate each hospital's risk-standardized 30-day serious adverse event rate, dividing hospitals into quartiles by performance. Hospitals located ≤30 miles of the remaining 20% of patients were compared, and 30-day serious adverse event rates and costs were simulated as if patients were treated at higher-quality hospitals using logistic regression with each alternative hospital's fixed-effect.

resultsWe identified 8,946 patients who underwent thyroid resection at 843 hospitals. Average risk-adjusted serious adverse event rates ranged from 13.9% to 52.9% between quartile 1 and 4 hospitals (P < .001). We identified higher-quality hospitals for 43.7% of patients. Simulating care at the best local hospital reduced predicted serious adverse event rates from 25.6% (95% confidence interval, 24.7-26.4) to 16.2% (95% confidence interval, 15.5-16.8; P < .001), while modestly lowering average costs from $12,883 (95% confidence interval, 12,500-13,267) to $12,679 (95% confidence interval, 12,304-13,056; P = .029).

conclusionSimulated care at higher-performing hospitals decreased serious adverse event rates after thyroid resection. Optimizing hospital selection may reduce postoperative morbidity without compromising preferences for local treatment.

Indexed as

AdenocarcinomaThyroid NeoplasmsAgedHospitalsHumansLogistic ModelsMedicareThyroidectomyUnited States

Identifiers

PMID36280510
PMCPMC10257995

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.