Evidence map›Paper›PMID 36280466›Full record

ArticleJournal of pediatric surgery2023

Long-term safety of intraluminal spring-mediated bowel lengthening.

Talha Rafeeqi, Veronica F Sullins, Anne-Laure Thomas, Justin P Wagner, Lauren S Y Wood, Fereshteh Salimi-Jazi, Andre Bessette, James C Y Dunn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Submucosal Hydrogel for Spring-Mediated Intestinal Lengthening.Journal of biomedical materials research. Part A · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Talha RafeeqiDivision of Pediatric Surgery, Stanford University, Stanford, CA, USA.
Veronica F SullinsDepartment of Surgery to University of California, Los Angeles, CA, USA.
Anne-Laure ThomasDivision of Pediatric Surgery, Stanford University, Stanford, CA, USA.
Justin P WagnerDepartment of Surgery to University of California, Los Angeles, CA, USA.
Lauren S Y WoodDivision of Pediatric Surgery, Stanford University, Stanford, CA, USA.
Fereshteh Salimi-JaziDivision of Pediatric Surgery, Stanford University, Stanford, CA, USA.
Andre BessetteEclipse Regenesis, Mountain View, CA, USA.
James C Y DunnDivision of Pediatric Surgery, Stanford University, Stanford, CA, USA; Eclipse Regenesis, Mountain View, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: jdunn2@stanford.edu.
Stanford University · USUniversity of California, Los Angeles · US

Funding

Outcomes study for the XL1 distraction enterogenesis device to improve nutrient absorption in short bowel syndrome patientsR44DK127658 · NIDDK · ECLIPSE ENTEROGENESIS, INC. · PI Andre Bessette · 2021 to 2026
$3.5M
NIDDK NIH HHS R44 DK127658
6 · The paper itself

Abstract

purposeThe purpose of the study is to examine the long-term safety of an endoluminal bowel lengthening device prior to its use in the first human trial. In addition, device performance and natural passage will be evaluated.

methodsEndoluminal lengthening springs were surgically placed into the jejunum of Yucatan minipigs using the Eclipse XL1 device. A matching internal control segment of jejunum was marked at the time of operation. Weekly weights and fluoroscopic studies were obtained to evaluate spring deployment and position until devices passed. Animals were euthanized at 28, 60, 90, and 180 days. At necropsy, length measurements were recorded, and histopathologic analysis was performed.

resultsThere were no bowel obstructions or overt perforations attributable to the device. All surviving animals gained weight and were clinically thriving. All devices passed out of the rectum by 180 days. Bowel lengthening was seen in all experimental segments, and minimal fibrosis was observed by 180 days.

conclusionJejunal lengthening persisted after device had passed through the intestinal tract after 180 days. Early histopathologic changes of the jejunum during distraction enterogenesis normalized over time.

Indexed as

Short Bowel SyndromeTissue Expansion DevicesAnimalsJejunumRectumSwine, MiniatureDistraction enterogenesisIntestinal lengtheningShort bowel syndrome

Identifiers

PMID36280466
PMCPMC13520693
OpenAlexW4297141333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.