Evidence map›Paper›PMID 36280271›Full record

ArticleJournal of cardiovascular imaging2022

Distribution of Aortic Root Calcium in Relation to Frame Expansion and Paravalvular Leakage After Transcatheter Aortic Valve Implantation (TAVI): An Observational Study Using a Patient-specific Contrast Attenuation Coefficient for Calcium Definition and Independent Core Lab Analysis of Paravalvular Leakage.

Nahid El Faquir, Quinten Wolff, Rafi Sakhi, Ben Ren, Zouhair Rahhab, Sander van Weenen, Patrick Geeve, Ricardo P J Budde, Eric Boersma, Joost Daemen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Predicting Coronary Occlusion Risk during Redo-TAVR at First TAVR: Asymmetric Calcification Causes Failure.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  2. Three-Year Outcomes With a Supra-Annular, Self-Expanding Bioprosthesis and a Pericardial Wrap-The FORWARD PRO Study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Nahid El FaquirDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-6718-5511
Quinten WolffDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-8664-7758
Rafi SakhiDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4699-9011
Ben RenDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Zouhair RahhabDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-1787-5749
Sander van WeenenDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Patrick GeeveDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.
Ricardo P J BuddeDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-3792-615X
Eric BoersmaDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2559-7128
Joost DaemenDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-8628-1410
Nicolas M van MieghemDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2732-1205
Peter P de JaegereDepartment of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. p.dejaegere@erasmusmc.nl.ORCID https://orcid.org/0000-0003-1540-0755
Cardialysis (Netherlands) · NLErasmus MC · NL

Funding

Abbott VascularACIST MedicalAstra ZenecaBoston Scientific CorporationMedtronic FoundationPie MedicalReCor Medical
6 · The paper itself

Abstract

backgroundCalcium is a determinant of paravalvular leakage (PVL) after transcatheter aortic valve implantation (TAVI). This is based on a fixed contrast attenuation value while X-ray attenuation is patient-dependent and without considering frame expansion and PVL location. We examined the role of calcium in (site-specific) PVL after TAVI using a patient-specific contrast attenuation coefficient combined with frame expansion.

methods57 patients were included with baseline CT, post-TAVI transthoracic echocardiography and rotational angiography (R-angio). Calcium load was assessed using a patient-specific contrast attenuation coefficient. Baseline CT and post-TAVI R-angio were fused to assess frame expansion. PVL was assessed by a core lab.

resultsOverall, the highest calcium load was at the non-coronary-cusp-region (NCR, 436 mm

conclusionsCalcium load was higher in patients with PVL and was an independent predictor of PVL. While calcium was predominantly seen at the NCR, PVL was most often at the LCR. These findings indicate that in addition to calcium, specific anatomic features play a role in PVL after TAVI.

Indexed as

Aortic stenosisMultimodal imagingTranscatheter aortic valve replacement

Identifiers

PMID36280271
PMCPMC9592252
OpenAlexW4285506282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.