Evidence map›Paper›PMID 36280234›Full record

ArticleEnvironmental science & technology2022

PFAS and Precursor Bioaccumulation in Freshwater Recreational Fish: Implications for Fish Advisories.

Heidi M Pickard, Bridger J Ruyle, Colin P Thackray, Adela Chovancova, Clifton Dassuncao, Jitka Becanova, Simon Vojta, Rainer Lohmann, Elsie M Sunderland

Abstract read
In one paragraph

Article in Environmental science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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  19. Hepatotoxicity in Carp (Animals : an open access journal from MDPI · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heidi M PickardHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-8312-7522
Bridger J RuyleHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-1941-4732
Colin P ThackrayHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-0439-3270
Adela ChovancovaHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States.
Clifton DassuncaoHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States.ORCID 0000-0001-7140-1344
Jitka BecanovaGraduate School of Oceanography, University of Rhode Island, Narragansett, Rhode Island 02882, United States.ORCID 0000-0002-3091-1054
Simon VojtaGraduate School of Oceanography, University of Rhode Island, Narragansett, Rhode Island 02882, United States.
Rainer LohmannGraduate School of Oceanography, University of Rhode Island, Narragansett, Rhode Island 02882, United States.ORCID 0000-0001-8796-3229
Elsie M SunderlandHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, United States.ORCID 0000-0003-0386-9548

Funding

Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Elsie Mareca Sunderland · 2017 to 2026
$18.9M
NIEHS NIH HHS P42 ES027706
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a diverse class of fluorinated anthropogenic chemicals that include perfluoroalkyl acids (PFAA), which are widely used in modern commerce. Many products and environmental samples contain abundant precursors that can degrade into terminal PFAA associated with adverse health effects. Fish consumption is an important dietary exposure source for PFAS that bioaccumulate in food webs. However, little is known about bioaccumulation of PFAA precursors. Here, we identify and quantify PFAS in recreational fish species collected from surface waters across New Hampshire, US, using a toolbox of analytical methods. Targeted analysis of paired water and tissue samples suggests that many precursors below detection in water have a higher bioaccumulation potential than their terminal PFAA. Perfluorobutane sulfonamide (FBSA), a short-chain precursor produced by electrochemical fluorination, was detected in all fish samples analyzed for this compound. The total oxidizable precursor assay interpreted using Bayesian inference revealed fish muscle tissue contained additional, short-chain precursors in high concentration samples. Suspect screening analysis indicated these were perfluoroalkyl sulfonamide precursors with three and five perfluorinated carbons. Fish consumption advisories are primarily being developed for perfluorooctane sulfonate (PFOS), but this work reinforces the need for risk evaluations to consider additional bioaccumulative PFAS, including perfluoroalkyl sulfonamide precursors.

Indexed as

Alkanesulfonic AcidsFluorocarbonsWater Pollutants, ChemicalAnimalsBayes TheoremBioaccumulationFishesFresh WaterSulfonamidesWaterAlkanesulfonic AcidsFluorocarbonsSulfonamidesWaterWater Pollutants, ChemicalBayesian inferencebioaccumulationconsumption advisoriesPFAS precursorsseafoodsuspect screeningtargeted analysistotal oxidizable precursor (TOP) assay

Identifiers

PMID36280234
PMCPMC9670858

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.