Evidence map›Paper›PMID 36280191›Full record

ReviewNitric oxide : biology and chemistry2022

Targeting hydrogen sulfide and nitric oxide to repair cardiovascular injury after trauma.

Saúl Huerta de la Cruz, Cindy L Santiago-Castañeda, Erick J Rodríguez-Palma, Grecia J Medina-Terol, Félix I López-Preza, Luisa Rocha, Araceli Sánchez-López, Kalev Freeman, David Centurión

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nitric oxide : biology and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Intracellular Crosstalk of the Gasotransmitter Trio (NO, CO, HInternational journal of molecular sciences · 2026
    Review
  2. Gas entrapping materials for damage control.Advanced drug delivery reviews · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Saúl Huerta de la CruzDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico; Department of Pharmacology, University of Vermont, Burlington, VT, USA. Electronic address: saulhuerta29@hotmail.com.
Cindy L Santiago-CastañedaDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico. Electronic address: cindy_2901@hotmail.com.
Erick J Rodríguez-PalmaNeurobiology of Pain Laboratory, Departamento de Farmacobiología, Cinvestav, Sede Sur, Mexico City, Mexico. Electronic address: ejosue26@hotmail.com.
Grecia J Medina-TerolDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico. Electronic address: grecia.medina@cinvestav.mx.
Félix I López-PrezaDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico. Electronic address: felix.lopez@cinvestav.mx.
Luisa RochaDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico. Electronic address: lrocha@cinvestav.mx.
Araceli Sánchez-LópezDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico. Electronic address: asanchezl@cinvestav.mx.
Kalev FreemanDepartment of Emergency Medicine, University of Vermont, Burlington, VT, USA. Electronic address: kalev.freeman@uvm.edu.
David CenturiónDepartamento de Farmacobiología, Cinvestav-Coapa, Mexico City, Mexico. Electronic address: dcenturi@cinvestav.mx.
Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXUniversity of Vermont · US

Funding

R35 Undergraduate Research SupplementR35GM144099 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kalev Freeman · 2022 to 2026
$2.2M
NIGMS NIH HHS R35 GM144099
6 · The paper itself

Abstract

The systemic cardiovascular effects of major trauma, especially neurotrauma, contribute to death and permanent disability in trauma patients and treatments are needed to improve outcomes. In some trauma patients, dysfunction of the autonomic nervous system produces a state of adrenergic overstimulation, causing either a sustained elevation in catecholamines (sympathetic storm) or oscillating bursts of paroxysmal sympathetic hyperactivity. Trauma can also activate innate immune responses that release cytokines and damage-associated molecular patterns into the circulation. This combination of altered autonomic nervous system function and widespread systemic inflammation produces secondary cardiovascular injury, including hypertension, damage to cardiac tissue, vascular endothelial dysfunction, coagulopathy and multiorgan failure. The gasotransmitters nitric oxide (NO) and hydrogen sulfide (H

Indexed as

Cardiovascular DiseasesCardiovascular SystemGasotransmittersHydrogen SulfideHumansNitric OxideGasotransmittersHydrogen SulfideNitric OxideBrain injuryCardiovascularHydrogen sulfideNitric oxide

Identifiers

PMID36280191
PMCPMC10644383
OpenAlexW4307043829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.