Evidence map›Paper›PMID 36279833›Full record

Trial reportSchizophrenia research2022

Motivational interviewing for loved ones: Randomized controlled trial of brief training for first episode psychosis caregivers.

Emily R Kline, Heather Thibeau, Beshaun J Davis, Alicia Fenley, Aliyah Simone Sanders, Bediha Ipekci, Rachel Oblath, Shirley Yen, Matcheri S Keshavan

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Schizophrenia research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07494071 (Pilot Evaluation of ReFrame-R), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07494071 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Evaluation of ReFrame-R: A Communication Training to Reframe Older Adults' Family Roles and Promote Active Aging

TypeinterventionalSponsorThe University of Hong KongRan2026 to 2028Enrolled40ConditionsIntergenerational RelationsArmsReFrame-R
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Emily R KlineBoston University School of Medicine, Department of Psychiatry, 720 Harrison Avenue, Boston, MA 02118, United States of America; Boston Medical Center, Department of Psychiatry, 850 Harrison Avenue, Boston, MA 02118, United States of America; Harvard Medical School, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America; Beth Israel Deaconess Medical Center, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America. Electronic address: Emily.Kline@BMC.org.
Heather ThibeauBoston Medical Center, Department of Psychiatry, 850 Harrison Avenue, Boston, MA 02118, United States of America; Beth Israel Deaconess Medical Center, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America.
Beshaun J DavisHarvard Medical School, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America; Beth Israel Deaconess Medical Center, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America.
Alicia FenleyBoston University, Department of Psychology, 900 Commonwealth Avenue, Boston, MA 02215, United States of America.
Aliyah Simone SandersBeth Israel Deaconess Medical Center, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America.
Bediha IpekciBoston University School of Medicine, Department of Psychiatry, 720 Harrison Avenue, Boston, MA 02118, United States of America; Boston Medical Center, Department of Psychiatry, 850 Harrison Avenue, Boston, MA 02118, United States of America.
Rachel OblathBoston University School of Medicine, Department of Psychiatry, 720 Harrison Avenue, Boston, MA 02118, United States of America; Boston Medical Center, Department of Psychiatry, 850 Harrison Avenue, Boston, MA 02118, United States of America.
Shirley YenHarvard Medical School, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America; Beth Israel Deaconess Medical Center, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America.
Matcheri S KeshavanHarvard Medical School, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America; Beth Israel Deaconess Medical Center, Department of Psychiatry, 75 Fenwood Road, Boston, MA 02215, United States of America.
Beth Israel Deaconess Medical Center · USBoston University · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Reducing Duration of Untreated Psychosis through Motivational Interviewing for Loved OnesK23MH118373 · NIMH · BOSTON MEDICAL CENTER · PI KLINE, EMILY R · 2019 to 2022
$638k
NCATS NIH HHS UL1 TR001430NIMH NIH HHS K23 MH118373
6 · The paper itself

Abstract

backgroundResearch shows that family involvement in psychosis treatment leads to better patient outcomes. Interventions that involve and counsel family members may improve patient outcomes by addressing barriers to treatment adherence and lowering family expressed emotion, thereby creating a less stressful and more supportive home environment. Learning to use motivational interviewing communication skills may help caregivers to decrease conflict and expressed emotion and improve treatment adherence.

methodsThe current study is a pilot randomized controlled trial testing the impact of "Motivational Interviewing for Loved Ones" (MILO), a brief five-hour psychoeducational intervention for caregivers, in a sample of family members of individuals with early course psychosis (N = 40). Using a randomized crossover design, caregivers were randomized to either immediate MILO or a six-week waitlist control condition; all participants eventually received the intervention.

resultsCaregiver participants experienced large (d = 1.08-1.43) and significant improvements in caregiver wellbeing, caregiver self-efficacy, family conflict, and expressed emotion. There was no change over time in caregiver-reported patient treatment adherence. Relative to waitlist, MILO had significant effects on family conflict and expressed emotion, a trending effect on perceived stress, and no effect on parenting self-efficacy or treatment adherence.

conclusionsMILO showed benefits for caregivers of FEP patients in this small, controlled trial. Further testing in a larger randomized controlled trial is warranted to better characterize MILO's effects for caregivers and patients across a range of diagnoses.

Indexed as

CaregiversPsychotic DisordersExpressed EmotionFamilyHumansSelf EfficacyCaregiverClinical trialFamilyFirst episode psychosisMotivational interviewingRandomized controlled trialSchizophrenia

Identifiers

PMID36279833
PMCPMC10593126
OpenAlexW4306987499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.