ReviewNeuroImage. Clinical2022
Hearing voices in the head: Two meta-analyses on structural correlates of auditory hallucinations in schizophrenia.
Review in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Meta-Analysis of Brain Volumetric Abnormalities in Patients with Remitted Major Depressive Disorder.Depression and anxiety · 2024Pooled it
- Deep transcranial magnetic stimulation for schizophrenia: a systematic review.Frontiers in psychiatry · 2024Pooled it
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Brain Structural and Functional Neuroimaging Features are Associated With Improved Auditory Hallucinations in Patients With Schizophrenia After Real-Time fMRI Neurofeedback.Depression and anxiety · 2025Trial
- Neural mechanism underlying the beneficial effect of Theory of Mind psychotherapy on early-onset schizophrenia: a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Structural alterations in early auditory cortex in borderline personality disorder with auditory verbal hallucinations.Brain structure & function · 2026Article
- Assessing the efficacy and safety of rTMS, tDCS, and DBS in treating auditory hallucinations: a scoping review.Frontiers in human neuroscience · 2026Review
- From neuronal to mental topography - Neurophenomenology of auditory hallucinations.Translational psychiatry · 2025Review
- Article
- Reactivity of Olanzapine and Tricyclic Antidepressants on the Protective Effects of Trolox on Lipid Peroxidation Evaluated Using Fluorescence Anisotropy, Electron Paramagnetic Resonance Spectrometry, and Thermal Analysis.ACS chemical neuroscience · 2025Article
- Alterations in sulcal depth and associated functional connectivity in schizophrenia with auditory verbal hallucinations.Frontiers in psychiatry · 2025Article
- Altered language-salience network connectivity in schizophrenia and differential associations with emotion regulation.Frontiers in psychiatry · 2025Article
- Intra-individual structural covariance network in schizophrenia patients with persistent auditory hallucinations.Schizophrenia (Heidelberg, Germany) · 2024Article
- Brain structural alterations associated with impulsiveness in male violent patients with schizophrenia.BMC psychiatry · 2024Article
- Functional Connectivity of Language-Related Cerebellar Regions Is Reduced in Schizophrenia Patients.Biomedicines · 2024Article
- Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.AIMS neuroscience · 2024Article
- Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.Frontiers in psychiatry · 2024Article
- fMRI fluctuations within the language network are correlated with severity of hallucinatory symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Language Network Connectivity of Euthymic Bipolar Patients Is Altered at Rest and during a Verbal Fluency Task.Biomedicines · 2023Article
- Investigating the lateralisation of experimentally induced auditory verbal hallucinations.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Past voxel-based morphometry (VBM) studies demonstrate reduced grey matter volume (GMV) in schizophrenia (SZ) patients' brains in various cortical and subcortical regions. Probably due to SZ symptoms' heterogeneity, these results are often inconsistent and difficult to integrate. We hypothesized that focusing on auditory verbal hallucinations (AVH) - one of the most common SZ symptoms - would allow reducing heterogeneity and discovering further compelling evidence of SZ neural correlates. We carried out two voxel-based meta-analyses of past studies that investigated the structural correlates of AVH in SZ. The review of whole-brain VBM studies published until June 2022 in PubMed and PsychInfo databases yielded (a) 13 studies on correlations between GMV and AVH severity in SZ patients (n = 472; 86 foci), and (b) 11 studies involving comparisons between hallucinating SZ patients (n = 504) and healthy controls (n = 524; 74 foci). Data were analyzed using the Activation Likelihood Estimation method. AVH severity was associated with decreased GMV in patients' left superior temporal gyrus (STG) and left posterior insula. Compared with healthy controls, hallucinating SZ patients showed reduced GMV on the left anterior insula and left inferior frontal gyrus (IFG). Our findings revealed important structural dysfunctions in a left lateralized cluster of brain regions, including the insula and temporo-frontal regions, that significantly contribute to the severity and persistence of AVH. Structural atrophy found in circuits involved in generating and perceiving speech, as well as in auditory signal processing, might reasonably be considered a biological marker of AVH in SZ.
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