Evidence map›Paper›PMID 36279718›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2022

The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A

Laura I Sarasola, Claudia Llinas Del Torrent, Andrea Pérez-Arévalo, Josep Argerich, Nil Casajuana-Martín, Andy Chevigné, Víctor Fernández-Dueñas, Sergi Ferré, Leonardo Pardo, Francisco Ciruela

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Cannabidiol negatively modulates adenosine AActa neuropsychiatrica · 2024
    Article
  7. Clues from a missense mutation of the adenosine ANeural regeneration research · 2023
    Article
  8. Unique effect of clozapine on adenosine ABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Article
  9. The World of GPCR dimers - Mapping dopamine receptor DComputational and structural biotechnology journal · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Laura I SarasolaPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain; Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Claudia Llinas Del TorrentLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma Barcelona, Bellaterra, 08193 Barcelona, Spain.
Andrea Pérez-ArévaloPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain; Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Josep ArgerichPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain; Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Nil Casajuana-MartínLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma Barcelona, Bellaterra, 08193 Barcelona, Spain.
Andy ChevignéImmuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Víctor Fernández-DueñasPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain; Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain.
Sergi FerréIntegrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. Electronic address: sferre@intra.nida.nih.gov.
Leonardo PardoLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma Barcelona, Bellaterra, 08193 Barcelona, Spain. Electronic address: Leonardo.Pardo@uab.es.
Francisco CiruelaPharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, 08907 L'Hospitalet de Llobregat, Spain; Neuropharmacology & Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, 08907 L'Hospitalet de Llobregat, Spain. Electronic address: fciruela@ub.edu.
Bellvitge University Hospital · ESUniversitat Autònoma de Barcelona · ESLuxembourg Institute of Health · LUNational Institutes of Health · US

Funding

Neurotransmitter Receptor Heteromers in the Striatal Spine ModuleZIADA000493 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI FERRE, SERGI · 2009 to 2025
$35.6M
Intramural NIH HHS ZIA DA000493
6 · The paper itself

Abstract

Adenosine modulates neurotransmission through inhibitory adenosine A

Indexed as

AdenosineParkinson DiseaseHEK293 CellsHumansMutationReceptor, Adenosine A1Receptors, Adenosine A2AdenosineReceptor, Adenosine A1Receptors, Adenosine A2A(1)R-A(2A)R heteromerAdenosine A(1) receptorConstitutive activityEarly-onset Parkinson’s disease

Identifiers

PMID36279718
PMCPMC11969171
OpenAlexW4307029753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.