ArticleAnnals of internal medicine2022
Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study.
Article in Annals of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Global Genetic Variation in Circulating 25-Hydroxyvitamin D: A Systematic Review of GWAS Evidence Across Different Ancestral Groups.Nutrients · 2026Pooled it
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- Pooled it
- Pooled it
- The "Selfish Cell": The Central Role of Metabolism in Relaying Environmental Stimuli and Controlling Cellular Function.Biology · 2026Review
- Article
- Does the Combination of Abdominal Obesity and Vitamin D Deficiency Increase the Risk of Death in Individuals Aged 50 or Older? Evidence From the ELSA Study.Diabetes, obesity & metabolism · 2026Article
- The Impact of Serum 25-Hydroxyvitamin D on Bone Mineral Density at Different Skeletal Sites: A Multivariate Analysis Based on a UK Cohort Study.Food science & nutrition · 2026Article
- Lack of Association between Vitamin D Insufficiency and Cardiovascular or Fracture Risk: A UK Biobank Study.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Association of Vitamin D Levels and Mortality in Overactive Bladder: Nonlinear Dose-Response and Threshold Effect.Food science & nutrition · 2026Article
- 25-Hydroxyvitamin D levels are associated with mortality and cardiovascular events in systemic lupus erythematosus.Annals of the rheumatic diseases · 2026Article
- Association of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality among individuals incardiovascular-kidney-metabolic syndrome stages 0-3: a cohort study from the NHANES 2001-2018.Diabetology & metabolic syndrome · 2026Article
- Article
- Evolving our understanding of vitamin D, periostin levels and cardiovascular risk in the elderly: a cross sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- The relationship between nutrition status indicators and vitamin D deficiency in patients with type 2 diabetes mellitus.Frontiers in nutrition · 2026Article
- Current Controversies on Adequate Circulating Vitamin D Levels in CKD.International journal of molecular sciences · 2025Review
- Vitamin D Deficiency at Hospital Admission With Community-Acquired Pneumonia is Associated With Increased Risk of Mortality: A Prospective Cohort Study.Open forum infectious diseases · 2025Article
- Vitamin D, premature mortality, and life expectancy among US adults.Archives of public health = Archives belges de sante publique · 2025Article
- Prevalence and correlates of vitamin D deficiency in primary school children of South Asian, White European, Black African and Caribbean and White European origin: a cross-sectional survey (2004-2007) in London, Birmingham and Leicester.The British journal of nutrition · 2025Article
- Non-Skeletal Roles of Vitamin D in Skin, Gut, and Cardiovascular Disease: Focus on Epithelial Barrier Function and Immune Regulation in Chronic Disease.International journal of molecular sciences · 2025Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
backgroundLow vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.
objectiveTo assess genetic evidence for the causal role of low vitamin D status in mortality.
designNonlinear Mendelian randomization analyses.
settingUK Biobank, a large-scale, prospective cohort from England, Scotland, and Wales with participants recruited between March 2006 and July 2010.
participants307 601 unrelated UK Biobank participants of White European ancestry (aged 37 to 73 years at recruitment) with available measurements of 25-hydroxyvitamin D (25-(OH)D) and genetic data. MEASUREMENTS: Genetically predicted 25-(OH)D was estimated using 35 confirmed variants of 25-(OH)D. All-cause and cause-specific mortality (cardiovascular disease [CVD], cancer, and respiratory) were recorded up to June 2020.
resultsThere were 18 700 deaths during the 14 years of follow-up. The association of genetically predicted 25-(OH)D with all-cause mortality was L-shaped ( LIMITATIONS: Analyses were restricted to a White European population. A genetic approach is best suited to providing proof of principle on causality, whereas the strength of the association is approximate.
conclusionOur study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels. PRIMARY FUNDING SOURCE: National Health and Medical Research Council.
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