ArticleProceedings of the National Academy of Sciences of the United States of America2022
Recurrent Hippocampo-neocortical sleep-state divergence in humans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- A-phase Occurrence During Sleep in the Deep Brain Recordings: Multiscale-Entropy and Multiscale-DFA Analysis.Brain topography · 2026Article
- A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep.Nature neuroscience · 2026Article
- Polysomnography in Transition: Reassessing Its Role in the Future of Sleep Medicine.Journal of sleep research · 2025Review
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A continuous approach to explain insomnia and subjective-objective sleep discrepancy.Communications biology · 2025Article
- Arousal threshold reveals novel neural markers of sleep depth independently from the conventional sleep stages.bioRxiv : the preprint server for biology · 2025Article
- An optimized framework for processing multicentric polysomnographic data incorporating expert human oversight.Frontiers in neuroinformatics · 2024Article
- Regional variability in intracerebral properties of NREM to REM sleep transitions in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A non-oscillatory, millisecond-scale embedding of brain state provides insight into behavior.bioRxiv : the preprint server for biology · 2023Article
- Using the electrodermal activity signal and machine learning for diagnosing sleep.Frontiers in sleep · 2023Article
- Spotlight on Sleep Stage Classification Based on EEG.Nature and science of sleep · 2023Article
- The functions of sleep: A cognitive neuroscience perspective.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Sleep is assumed to be a unitary, global state in humans and most other animals that is coordinated by executive centers in the brain stem, hypothalamus, and basal forebrain. However, the common observation of unihemispheric sleep in birds and marine mammals, as well as the recently discovered nonpathological regional sleep in rodents, calls into question whether the whole human brain might also typically exhibit different states between brain areas at the same time. We analyzed sleep states independently from simultaneously recorded hippocampal depth electrodes and cortical scalp electrodes in eight human subjects who were implanted with depth electrodes for pharmacologically intractable epilepsy evaluation. We found that the neocortex and hippocampus could be in nonsimultaneous states, on average, one-third of the night and that the hippocampus often led in asynchronous state transitions. Nonsimultaneous bout lengths varied from 30 s to over 30 min. These results call into question the conclusions of studies, across phylogeny, that measure only surface cortical state but seek to assess the functions and drivers of sleep states throughout the brain.
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