ArticleProceedings of the National Academy of Sciences of the United States of America2022
Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Humans can use positive and negative spectrotemporal correlations to detect rising and falling pitch.Nature human behaviour · 2026Article
- Sound feature representations decorrelate across the mouse auditory pathway.PLoS biology · 2025Article
- Chirp sensitivity and vowel coding in the inferior colliculus.Hearing research · 2025Article
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- Distinct cell classes in the superior paraolivary nucleus (SPN) region in the gerbil auditory brainstem revealed by in vivo physiological and anatomical characterization.Hearing research · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.Nature communications · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Molecular Cascades That Build and Connect Auditory Neurons from Hair Cells to the Auditory Cortex.Journal of experimental neurology · 2025Article
- A computational model of auditory chirp-velocity sensitivity and amplitude-modulation tuning in inferior colliculus neurons.Journal of computational neuroscience · 2024Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.bioRxiv : the preprint server for biology · 2024Article
- Asymmetry in the Perception of Electrical Chirps Presented to Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain.Annual review of neuroscience · 2024Review
- A Computational Model of Auditory Chirp-Velocity Sensitivity and Amplitude-Modulation Tuning in Inferior Colliculus Neurons.Research square · 2024Article
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- Sensitivity to direction and velocity of fast frequency chirps in the inferior colliculus of awake rabbit.Hearing research · 2023Article
- Mechanisms of masking by Schroeder-phase harmonic tone complexes in the budgerigar (Melopsittacus undulatus).Hearing research · 2023Article
- Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus.eNeuro · 2023Article
- Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Octopus cells are remarkable projection neurons of the mammalian cochlear nucleus, with extremely fast membranes and wide-frequency tuning. They are considered prime examples of coincidence detectors but are poorly characterized in vivo. We discover that octopus cells are selective to frequency sweep direction, a feature that is absent in their auditory nerve inputs. In vivo intracellular recordings reveal that direction selectivity does not derive from across-frequency coincidence detection but hinges on the amplitudes and activation sequence of auditory nerve inputs tuned to clusters of hot spot frequencies. A simple biophysical octopus cell model excited with real nerve spike trains recreates direction selectivity through interaction of intrinsic membrane conductances with the activation sequence of clustered excitatory inputs. We conclude that octopus cells are sequence detectors, sensitive to temporal patterns across cochlear frequency channels. The detection of sequences rather than coincidences is a much simpler but powerful operation to extract temporal information.
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