ArticleProceedings of the National Academy of Sciences of the United States of America2022
Sleep deprivation and hippocampal ripple disruption after one-session learning eliminate memory expression the next day.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Article
- Offline generative network reconfiguration guides insight-like accelerated learning by assimilation into schema in rats.Nature communications · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Home-based sleep monitoring reveals associations between amyloid accumulation and sleep alterations in individuals with subjective and mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.CNS neuroscience & therapeutics · 2026Article
- High frequency head impact exposure changes hippocampal sharp-wave ripple architecture.PloS one · 2026Article
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality.iScience · 2025Article
- Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus.iScience · 2025Article
- Memory reactivation generates new, adaptive behaviours that reach beyond direct experience.Scientific reports · 2024Article
- Five percent CONeuroprotection (Chichester, England) · 2024Article
- Prefrontal cortical ripples mediate top-down suppression of hippocampal reactivation during sleep memory consolidation.Current biology : CB · 2024Article
- Memory Reactivation during Sleep Does Not Act Holistically on Object Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Paradoxical replay can protect contextual task representations from destructive interference when experience is unbalanced.bioRxiv : the preprint server for biology · 2024Article
- Rodent maze studies: from following simple rules to complex map learning.Brain structure & function · 2024Review
- Article
- Memory reactivation during sleep does not act holistically on object memory.bioRxiv : the preprint server for biology · 2024Article
- Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Sleep deprivation-induced memory impairment: exploring potential interventions.Frontiers in psychiatry · 2024Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory reactivation during non-rapid-eye-movement ripples is thought to communicate new information to a systems-wide network and thus can be a key player mediating the positive effect of sleep on memory consolidation. Causal experiments disrupting ripples have only been performed in multiday training paradigms, which decrease but do not eliminate memory performance, and no comparison with sleep deprivation has been made. To enable such investigations, we developed a one-session learning paradigm in a Plusmaze and show that disruption of either sleep with gentle handling or hippocampal ripples with electrical stimulation impaired long-term memory. Furthermore, we detected hippocampal ripples and parietal high-frequency oscillations after different behaviors, and a bimodal frequency distribution in the cortical events was observed. Faster cortical high-frequency oscillations increased after normal learning, a change not seen in the hippocampal ripple-disruption condition, consistent with these having a role in memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.