ArticleProceedings of the National Academy of Sciences of the United States of America2022
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
What it found
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Who cites it
30 citing papers in PubMed, 39 citations in OpenAlex.
- Super-enhancer-driven SGK1 activates polyamine metabolism to promote autoimmune uveitis.Science advances · 2026Article
- Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1-FOXO1 Signaling to Enhance ILC3s Effector Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- miR-9394b from Lactobacillus paracasei extracellular vesicles targets iNOS to reprogram host NO-ornithine metabolism and ameliorate DSS-induced murine colitis.NPJ biofilms and microbiomes · 2026Article
- Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne.Nature communications · 2026Article
- Metabolic regulation of gut barrier integrity in IBD: protein, lipid, and carbohydrate pathways.Frontiers in nutrition · 2026Review
- Trained Immunity in Bladder ILC3s Enhances Mucosal Defense Against Recurrent Urinary Tract Infections.Biomedicines · 2025Article
- Regulation of innate lymphoid cell by microbial metabolites.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control.The Journal of experimental medicine · 2025Article
- Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Deciphering the Role of Innate Lymphoid Cells Group 3 in the Gut Microenvironment: A Narrative Review of Their Novel Contributions to Autoimmune Disease Pathogenesis.Journal of inflammation research · 2025Review
- Knowledge mapping and research trends of IL-22 from 2014 to 2023: A bibliometric analysis.Human vaccines & immunotherapeutics · 2024Article
- Review
- IL-22, a vital cytokine in autoimmune diseases.Clinical and experimental immunology · 2024Review
- Identifying polyamine related biomarkers in diagnosis and treatment of ulcerative colitis by integrating bulk and single-cell sequencing data.Scientific reports · 2024Article
- OLFM4 modulates intestinal inflammation by promoting IL-22Communications biology · 2024Article
- The IRE1α/XBP1 pathway sustains cytokine responses of group 3 innate lymphoid cells in inflammatory bowel disease.The Journal of clinical investigation · 2024Article
- Age-specific Metabolomic profiles in children with food allergy.Clinical immunology (Orlando, Fla.) · 2024Article
- Systematic review of metabolomic alterations in ulcerative colitis: unveiling key metabolic signatures and pathways.Therapeutic advances in gastroenterology · 2024Review
- Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis.Theranostics · 2024Article
- Metabolism of Polyamines and Kidney Disease: A Promising Therapeutic Target.Kidney diseases (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Vincent PengDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Siyan CaoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-3740-2164
Tihana TrsanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Jennifer K BandoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-1331-7424
Julian Avila-PachecoBroad Institute, Cambridge, MA 02412.
John L ClevelandDepartment of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612.
Clary ClishBroad Institute, Cambridge, MA 02412.
Ramnik J XavierBroad Institute, Cambridge, MA 02412.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-5222-4987
Washington University in St. Louis · USBroad Institute · USMoffitt Cancer Center · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MCLINICAL/LABORATORY TRAINING ACADEMIC GASTROENTEROLOGYT32DK007130 · NIDDK · WASHINGTON UNIVERSITY · PI MATTHEW AARON CIORBA · 1986 to 2026
$8.3MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MATG16L1 T300A: genetics to biologyR01DK097485 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2013 to 2021
$4.1MLysosome Homeostasis and Microbicidal Mechanisms in Innate ImmunityR01DK117263 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2018 to 2021
$2.4MPlasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4MImmune Checkpoints for Intestinal Innate Lymphoid CellsR00DK118110 · NIDDK · STANFORD UNIVERSITY · PI BANDO, JENNIFER KAORU · 2021 to 2023
$747kImpact of polyamines on ILC3 function at steady state and in preclinical model of colitisR21AI159210 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2022 to 2023
$431kDetermining the contribution of polyamine biosynthesis to the function of group 3 innate lymphoid cells in the gastrointestinal systemF30DK127540 · NIDDK · WASHINGTON UNIVERSITY · PI PENG, VINCENT · 2020 to 2022
$106kNCI NIH HHS P30 CA091842NIAID NIH HHS R21 AI159210NIDDK NIH HHS F30 DK127540NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R00 DK118110NIDDK NIH HHS R01 DK097485NIDDK NIH HHS R01 DK117263NIDDK NIH HHS R01 DK124699NIDDK NIH HHS T32 DK007130NIDDK NIH HHS T32 DK077653
Abstract
Group 3 innate lymphoid cells (ILC3s) are RORγT
Indexed as
ColitisEnterobacteriaceae InfectionsAnimalsAnti-Bacterial AgentsImmunity, InnateInterleukin-17Interleukin-22MiceNuclear Receptor Subfamily 1, Group F, Member 3OrnithineOrnithine DecarboxylasePutrescineTh17 CellsAnti-Bacterial AgentsInterleukin-17Interleukin-22Nuclear Receptor Subfamily 1, Group F, Member 3OrnithineOrnithine DecarboxylasePutrescineenteritisIL-22innate lymphoid cellsornithine decarboxylasepolyamines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.