Evidence map›Paper›PMID 36279397›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2022

Differential Activation and Desensitization States Promoted by Noncanonical

Clare Stokes, Gisela Andrea Camacho-Hernandez, Ganesh A Thakur, Xiaoxuan Wu, Palmer Taylor, Roger L Papke

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Clare StokesDepartment of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (G.A.C.-H., X.W., P.T.); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (C.S., R.L.P.); and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (G.A.T.).
Gisela Andrea Camacho-HernandezDepartment of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (G.A.C.-H., X.W., P.T.); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (C.S., R.L.P.); and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (G.A.T.).
Ganesh A ThakurDepartment of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (G.A.C.-H., X.W., P.T.); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (C.S., R.L.P.); and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (G.A.T.).
Xiaoxuan WuDepartment of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (G.A.C.-H., X.W., P.T.); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (C.S., R.L.P.); and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (G.A.T.).
Palmer TaylorDepartment of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (G.A.C.-H., X.W., P.T.); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (C.S., R.L.P.); and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (G.A.T.).
Roger L PapkeDepartment of Pharmacology, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (G.A.C.-H., X.W., P.T.); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (C.S., R.L.P.); and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (G.A.T.) rlpapke@ufl.edu.ORCID 0000-0002-4468-8658
Northeastern University · US

Funding

Targeting of Alpha7 nAChR for therapeutic effectsR01GM057481 · NIGMS · UNIVERSITY OF FLORIDA · PI PAPKE, ROGER L · 2000 to 2023
$7.6M
KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONR37GM018360 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, PALMER WILLIAM · 1999 to 2008
$5.7M
A Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2M
NEI NIH HHS R01 EY024717NIGMS NIH HHS R01 GM057481NIGMS NIH HHS R37 GM018360
6 · The paper itself

Abstract

A series of dipicolyl amine pyrimidines (DPPs) were previously identified as potential

Indexed as

QuinolinesReceptors, NicotinicAcetylcholineAllosteric Regulationalpha7 Nicotinic Acetylcholine ReceptorAnimalsCalciumEpitopesHumansNicotinic AgonistsPyrimidinesSulfonamidesXenopus laevisAcetylcholinealpha7 Nicotinic Acetylcholine ReceptorCalciumEpitopesNicotinic AgonistsPyrimidinesQuinolinesReceptors, NicotinicSulfonamides

Identifiers

PMID36279397
PMCPMC9553115
OpenAlexW4294286638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.