Evidence map›Paper›PMID 36279096›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2022

Quantitative analysis of Merkel cell polyomavirus (MCPyV) genome in non-melanoma skin cancer and normal tumor margins.

Ali Hasanzadeh, Farzin Sadeghi, Ghodsieh Kamrani, Neda Mohammadi, Zeinab Vosough, Mohammad Ranaee, Alijan Tabarraei, Yousef Yahyapour

Open access · greenAbstract read
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In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ali HasanzadehDepartment of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Farzin SadeghiCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Ghodsieh KamraniDepartment of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Neda MohammadiDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Zeinab VosoughDepartment of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Mohammad RanaeeDepartment of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Alijan TabarraeiInfectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran. tabarraei@goums.ac.ir.
Yousef YahyapourInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. uyahyapoor@yahoo.com.ORCID http://orcid.org/0000-0002-8823-8042
Babol University of Medical Sciences · IRGolestan University · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Merkel cell polyomavirus (MCPyV) is the cause of approximately 80% of Merkel cell carcinomas (MCC). The common types of non-melanoma skin cancer (NMSC) including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are histologically similar to MCC. In the present study, 58 NMSC formalin-fixed paraffin-embedded tissue (FFPE) samples including 12 SCC, 46 BCC, and 58 FFPE samples of adjacent non-tumoral margins as the control were included. Determination of large tumor antigens (LTAg) copy number was performed by qReal-Time PCR as a viral copy number per cell to elucidate MCPyV carcinogenic role in non-melanoma skin cancer. Out of 58 samples, 36 (62%) cancerous and 22 (37.9%) normal tumor margins were positive for MCPyV LTAg. Median copy numbers of MCPyV LTAg among all NMSC samples and non-tumoral margins were 0.308×10

Indexed as

Basal Cell CarcinomaCarcinoma, Merkel CellCarcinoma, Squamous CellMerkel cell polyomavirusSkin NeoplasmsTumor Virus InfectionsDNA, ViralHumansDNA, ViralBasal cell carcinoma (BCC)Large T-antigen (LTAg)Merkel cell polyomavirus (MCPyV)Non-melanoma skin cancer (NMSC)Skin cancerSquamous cell carcinoma (SCC)

Identifiers

PMID36279096
PMCPMC9679045
OpenAlexW4307178540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.