ArticleJournal of the American Chemical Society2022
Copper-Catalyzed Three-Component Aminofluorination of Alkenes and 1,3-Dienes: Direct Entry to Diverse β-Fluoroalkylamines.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Copper-Catalyzed Amino Radical Transfer-Mediated Deborylation for Chiral Ester Synthesis.Angewandte Chemie (International ed. in English) · 2026Article
- Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.Angewandte Chemie (International ed. in English) · 2026Article
- Copper-Catalyzed Asymmetric Amino Lactonization of Alkenes: Direct Access to Enantioenriched 1,2-Alkylamino Alcohol Derivatives.Journal of the American Chemical Society · 2026Article
- Article
- Enantioselective Syntheses of Secondary Alkylboronates via Asymmetric Regioselective Reduction of 1,3-Dienylboronates.Angewandte Chemie (International ed. in English) · 2026Article
- Three-component synthesis of β-thio tertiary alkylamines from simple alkenes via SScience advances · 2026Article
- Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines.Nature communications · 2025Article
- Three-Component Catalytic Amino Etherification of Alkenes: Enabled by Silyl Ether-Promoted C-O Coupling.ACS catalysis · 2025Article
- Copper-Catalyzed Allylic Amination of Alkenes UsingACS catalysis · 2025Article
- Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO.Journal of the American Chemical Society · 2025Article
- Incorporating azaheterocycle functionality in intramolecular aerobic, copper-catalyzed aminooxygenation of alkenes.RSC advances · 2024Article
- Dienes as Versatile Substrates for Transition Metal-Catalyzed Reactions.Angewandte Chemie (International ed. in English) · 2024Review
- A Catalytic Three-Component Aminofluorination of Unactivated Alkenes with Electron-Rich Amino Sources.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Copper-catalyzed generation of nitrogen-centered radicals and reactions thereof.ARKIVOC : free online journal of organic chemistry · 2024Article
- Copper-Catalyzed Asymmetric Acylboration of 1,3-Butadienylboronate with Acyl Fluorides.Angewandte Chemie (International ed. in English) · 2023Article
- Highlights on U.S. FDA-approved fluorinated drugs over the past five years (2018-2022).European journal of medicinal chemistry · 2023Review
- Development of New Reactions Driven by N-O Bond Cleavage: fromSynlett : accounts and rapid communications in synthetic organic chemistry · 2023Article
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4 authors.
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Abstract
Rapid and efficient access to structurally diverse β-fluoroalkylamines is in high demand, with their wide presence and great importance in medicinal chemistry and drug development. Direct 1,2-aminofluorination of alkenes offers an ideal strategy for one-step entry to β-fluorinated amines from readily available starting materials. Yet the synthesis of valuable β-fluorinated alkylamines remains an unsolved challenge, due to the inherent incompatibility between electrophilic fluoride sources and the electron-rich alkylamines. We report an unprecedented, catalytic, three-component aminofluorination of diverse alkenes and 1,3-dienes, which has been achieved by an innovative copper-catalyzed electrophilic amination strategy using
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