Evidence map›Paper›PMID 36278800›Full record

ArticleChemical communications (Cambridge, England)2022

A phosphine-based redox method for direct conjugation of disulfides.

Yong Lu, Lin You, Chuo Chen

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yong LuDepartment of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA. Chuo.Chen@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-3656-3185
Lin YouDepartment of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA. Chuo.Chen@UTSouthwestern.edu.ORCID http://orcid.org/0000-0003-1162-0064
Chuo ChenDepartment of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA. Chuo.Chen@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-3118-4901
The University of Texas Southwestern Medical Center · US

Funding

Explore the therapeutic potential of small-molecule immune modulatorsR01CA226419 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, CHUO · 2019 to 2023
$1.9M
A New Chemical Technology for Biological Studies and Therapeutic ApplicationsR21GM137179 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, CHUO · 2020 to 2021
$450k
NCI NIH HHS R01 CA226419NIGMS NIH HHS R21 GM137179
6 · The paper itself

Abstract

Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols. We describe herein Redox-assisted Disulfide Direct Conjugation (RDDC) as a new method to enable disulfide rebridging without cross-reacting with free thiols.

Indexed as

DisulfidesPhosphinesOxidation-ReductionSulfhydryl CompoundsDisulfidesphosphinePhosphinesSulfhydryl Compounds

Identifiers

PMID36278800
PMCPMC9661873
OpenAlexW4307181701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.