ReviewJournal of functional biomaterials2022
Calcium Phosphate-Based Biomaterials for Bone Repair.
Review in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 259 citations in OpenAlex.
- Unleashing innovation: 3D-printed biomaterials in bone tissue engineering for repairing femur and tibial defects in animal models - a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2024Pooled it
- Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications.Bioactive materials · 2027Review
- Effect of Alginate Coatings on Hydroxyapatite/β-Tricalcium Phosphate Scaffold Behavior.Journal of functional biomaterials · 2026Article
- Injectable Hydroxyapatite and Tetracalcium Phosphate Granules Combined with Autologous Bone Marrow Concentrate: Toward Shape-Adaptive, Single-Step Bone Regeneration.Journal of functional biomaterials · 2026Article
- Current and emerging biomaterials for targeted drug delivery in osteomyelitis management.Discover nano · 2026Review
- Enzyme-Responsive Composite Hydrogel Coating Containing Nano-HA/Nano-ZnO with Pro-Osteogenic and Anti-Osteoclastic Properties.Macromolecular bioscience · 2026Article
- Lateral Ridge Augmentation Using Low-dosage Bone Morphogenetic Protein-2 Functionalised Calcium Phosphate Cement.International dental journal · 2026Article
- Unexpected periosteal bone apposition including newly embedded osteocytes occurs around a mouse calvaria critical defect, independently of the presence of biomaterials.Scientific reports · 2026Article
- Comparative Evaluation of β-TCP-Based Composite Biomaterials Using Chorionic Mesenchymal Stem Cells Under Non-Osteogenic Conditions.Polymers · 2026Article
- Biocomposites of Alginate, Calcium Polyphosphate, and Silver Nanostructures: Antibacterial Systems for Bone Regeneration Applications.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Article
- Calcium Phosphate Nanostructured Biocomposites with Applications in Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Review
- Exploring the bioactive potential of bovine pericardium membrane combined with hyaluronic Acid: characterization and cellular viability analyses.Biochemistry and biophysics reports · 2026Article
- The potential use of tetracalcium phosphate in vertebral augmentation: A study in a sheep model.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Robust adhesion between solid-state hydroxyapatite and bone tissue through surface demineralization.Bioactive materials · 2026Article
- Digital Manufacturing of Calcium Phosphate-Based Dental Materials: From Design to Clinical Use.Materials (Basel, Switzerland) · 2026Review
- Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo.Acta biomaterialia · 2026Article
- Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair.Bioactive materials · 2026Article
- Dental Implant Osseointegration Following Mandibular Augmentation Using 3D Printed Hydroxyapatite Blocks. An Experimental In Vivo Study.Clinical oral implants research · 2026Article
- Dual pH-Responsive Calcium Phosphate Nanoparticles Conjugated with Folate by CuAAC Click Chemistry for Targeted Gemcitabine Delivery to Cancer Cells.ACS applied bio materials · 2026Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Traumatic, tumoral, and infectious bone defects are common in clinics, and create a big burden on patient's families and society. Calcium phosphate (CaP)-based biomaterials have superior properties and have been widely used for bone defect repair, due to their similarities to the inorganic components of human bones. The biological performance of CaPs, as a determining factor for their applications, are dependent on their physicochemical properties. Hydroxyapatite (HAP) as the most thermally stable crystalline phase of CaP is mostly used in the form of ceramics or composites scaffolds with polymers. Nanostructured CaPs with large surface areas are suitable for drug/gene delivery systems. Additionally, CaP scaffolds with hierarchical nano-/microstructures have demonstrated excellent ability in promoting bone regeneration. This review focuses on the relationships and interactions between the physicochemical/biological properties of CaP biomaterials and their species, sizes, and morphologies in bone regeneration, including synthesis strategies, structure control, biological behavior, and the mechanisms of CaP in promoting osteogenesis. This review will be helpful for scientists and engineers to further understand CaP-based biomaterials (CaPs), and be useful in developing new high-performance biomaterials for bone repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.