Evidence map›Paper›PMID 36278643›Full record

ArticleJournal of functional biomaterials2022

Meropenem/Vaborbactam and Cefiderocol as Combination or Monotherapy to Treat Multi-Drug Resistant Gram-Negative Infections: A Regional Cross-Sectional Survey from Piedmont Infectious Disease Unit Network (PIDUN).

Tommaso Lupia, Silvia Corcione, Nour Shbaklo, Giorgia Montrucchio, Ilaria De Benedetto, Valentina Fornari, Roberta Bosio, Barbara Rizzello, Simone Mornese Pinna, Luca Brazzi and 1 more

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tommaso LupiaUnit of Infectious Diseases, Cardinal Massaia, 14100 Asti, Italy.ORCID 0000-0002-3865-9519
Silvia CorcioneDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.
Nour ShbakloDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-0171-9274
Giorgia MontrucchioDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.
Ilaria De BenedettoDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.
Valentina FornariDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.
Roberta BosioDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.
Barbara RizzelloDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.
Simone Mornese PinnaDepartment of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-0148-1075
Luca BrazziDepartment of Surgical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-7059-0622
Francesco Giuseppe De RosaUnit of Infectious Diseases, Cardinal Massaia, 14100 Asti, Italy.ORCID 0000-0001-8338-0130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meropenem/vaborbactam (MV) and cefiderocol were recently approved by the Food and Drug Administration and European Medicines Agency and are among the most promising antibacterial in treatment regimens against multi-drug resistant (MDR) gram-negative bacilli. A survey with close-ended questions was proposed to infectious disease (ID) and intensive care unit (ICU) physicians of Piedmont and Valle d'Aosta Region's hospitals. The aim was to collect data about habits and prescriptions of cefiderocol and MV. Twenty-three physicians (11 ID specialists and 12 anesthesiologists) in 13 Italian hospitals took part in the survey. Both cefiderocol and MV were mostly used as target therapy after a previous treatment failure and after ID specialist consult. The most frequent MDR pathogen in hospitals was

Indexed as

cefiderocolintensive care unitmeropenem/vaborbactammulti-drug resistantstewardshipsurvey

Identifiers

PMID36278643
PMCPMC9624317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.