Evidence map›Paper›PMID 36278635›Full record

ArticleJournal of functional biomaterials2022

The Effect of a Dodecahedron-Shaped Structure on the Properties of an Enzyme.

Yuri D Ivanov, Vadim Y Tatur, Ivan D Shumov, Andrey F Kozlov, Anastasia A Valueva, Irina A Ivanova, Maria O Ershova, Nina D Ivanova, Igor N Stepanov, Andrei A Lukyanitsa and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yuri D IvanovInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.
Vadim Y TaturFoundation of Perspective Technologies and Novations, 115682 Moscow, Russia.
Ivan D ShumovInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.ORCID 0000-0002-9795-7065
Andrey F KozlovInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.
Anastasia A ValuevaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.
Irina A IvanovaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.
Maria O ErshovaInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.
Nina D IvanovaFoundation of Perspective Technologies and Novations, 115682 Moscow, Russia.
Igor N StepanovFoundation of Perspective Technologies and Novations, 115682 Moscow, Russia.
Andrei A LukyanitsaFoundation of Perspective Technologies and Novations, 115682 Moscow, Russia.
Vadim S ZiborovInstitute of Biomedical Chemistry, Pogodinskaya Str., 10 Build. 8, 119121 Moscow, Russia.
Institute of Biomedical Chemistry · RULomonosov Moscow State University · RUMoscow State Academy of Veterinary Medicine and Biotechnology named after Skryabin · RU

Funding

The Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers "Digital bi-odesign and personalized healthcare" 075-15-2022-305
6 · The paper itself

Abstract

In this research, the influence of a dodecahedron-shaped structure on the adsorption behavior of a horseradish peroxidase (HRP) enzyme glycoprotein onto mica substrates was studied. In the experiments, samples of an aqueous HRP solution were incubated at various distances (0.03 m, 2 m, 5 m, and control at 20 m) from the dodecahedron surface. After the incubation, the direct adsorption of HRP onto mica substrates immersed in the solutions was performed, and the mica-adsorbed HRP particles were visualized via atomic force microscopy (AFM). The effect of the increased HRP aggregation was only observed after the incubation of the enzyme solution at the 2 m distance from the dodecahedron. In addition, with respect to the control sample, spectrophotometric measurements revealed no change in the HRP enzymatic activity after the incubation at any of the distances studied. The results reported herein can be of use in the modeling of the possible influences of various spatial structures on biological objects in the development of biosensors and other electronic equipment.

Indexed as

atomic force microscopybiosensordodecahedral structureelectromagnetic fieldenzyme adsorptionprotein aggregation

Identifiers

PMID36278635
PMCPMC9590084
OpenAlexW4297477472

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.