ArticleThe Korean journal of internal medicine2022
Association between serum ferritin levels and colorectal cancer risk in Korea.
Article in The Korean journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Prognostic value of preoperative serum ferritin in cholangiocarcinoma patients.Scientific reports · 2025Article
- Comprehensive approaches to diabetes in the elderly: adapting to evolving trends.The Korean journal of internal medicine · 2025Article
- Review
- Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram.World journal of gastroenterology · 2025Article
- Decoding metabolic dysfunction in cancer: foundations for early detection and personalized therapeutics.Frontiers in endocrinology · 2025Review
- Association between serum iron status and the risk of colorectal cancer in US adults: a cross-sectional analysis of NHANES 2001-2020.BMC gastroenterology · 2024Article
- Serum ferritin and the risk of early-onset colorectal cancer.World journal of gastrointestinal oncology · 2024Article
- Serum ferritin and risk of colonic neoplasia: Implications for the workup and treatment of iron deficiency.European journal of haematology · 2024Review
- Iron and cancer: overview of the evidence from population-based studies.Frontiers in oncology · 2024Review
- Diabetes Mellitus in the Elderly Adults in Korea: Based on Data from the Korea National Health and Nutrition Examination Survey 2019 to 2020.Diabetes & metabolism journal · 2023Article
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4 authors.
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Abstract
BACKGROUND/
aimsThe concentration of serum ferritin, a storage form of iron, may be associated with carcinogenesis in various cancers. There are only limited studies on the relationship between serum ferritin levels and colorectal cancer (CRC) risk, especially in the Asian population. This study aimed to analyze the association between CRC incidence and serum ferritin levels.
methodsThis was a national cohort study that used health checkup and insurance claims data of the Korean population. CRC incidence according to the serum ferritin level was analyzed during 2008-2018 in 17,116 participants.
resultsThe hazard ratio (HR) of CRC incidence decreased as serum ferritin levels increased (Q1: HR, 1.000 [95% confidence interval [CI], reference]; Q2: HR, 0.811 [95% CI, 0.558 to 1.178]; Q3: HR, 0.654 [95% CI, 0.442 to 0.968]; Q4: HR, 0.443 [95% CI, 0.285 to 0.687]; p = 0.0026). In subgroup analysis, 40 to 64 years of age, sex, body mass index of < 25 kg/ m2, presence of metabolic syndrome, absence of diabetes mellitus, and absence of anemia had HRs of < 0.5 (95% CI) in the highest quartiles compared with that in the lowest quartiles.
conclusionThis study shows an inverse association between serum ferritin and CRC risk. Serum ferritin measurement can aid in identifying young adults requiring active CRC screening.
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