ReviewBiomedical reports2022
Role of hyaluronic acid in periodontal therapy (Review).
Review in Biomedical reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Palatal groove associated with periodontal lesions: a systematic review illustrated by a decisional tree for management.BMC oral health · 2024Pooled it
- Comparative evaluation of hyaluronic acid spray and low-level laser therapy on wound healing following gingivectomy: a randomized controlled clinical trial.Lasers in medical science · 2026Trial
- Clinical and radiographic evaluation of local application of insulin versus hyaluronic acid using resorbable collagen sponge in management of periodontal intra-bony defects: a pilot randomized controlled clinical trial.Clinical oral investigations · 2026Trial
- Local delivery of hyaluronan and minocycline as an adjunct to subgingival instrumentation in the treatment of stage II grade B diabetic periodontitis: a randomized split-mouth clinical and microbiological study.Clinical oral investigations · 2025Trial
- Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial.BMC oral health · 2025Trial
- Review
- Hyaluronic acid versus microneedling with injectable platelet-rich fibrin in the treatment of partial loss of interdental papillae: A pilot randomized clinical trial.The Saudi dental journal · 2026Article
- Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation.Gels (Basel, Switzerland) · 2026Review
- Exploring the bioactive potential of bovine pericardium membrane combined with hyaluronic Acid: characterization and cellular viability analyses.Biochemistry and biophysics reports · 2026Article
- The Role of Hyaluronic Acid in the Treatment of Gingivitis and Periodontitis at Different Stages: A Systematic Review and Meta-Analysis with Short-Term Follow-Up.Bioengineering (Basel, Switzerland) · 2025Review
- Locally delivered 1% metformin gel improves periodontal parameters: A systematic review and meta-analysis.The Saudi dental journal · 2025Review
- The efficacy of hyaluronic acid treatment on induced periodontitis in rats exposed to gamma radiation.Scientific reports · 2025Article
- Review
- A Three-Month Clinical Trial on the Efficacy of Hyaluronic Acid Adjunctive Non-Surgical Therapy for Periodontitis in Patients with Type 2 Diabetes Mellitus.Biomedicines · 2024Article
- Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis.European journal of dentistry · 2024Article
- Bidirectional Association between Periodontitis and Thyroid Disease: A Scoping Review.International journal of environmental research and public health · 2024Article
- From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- The molecular weight of hyaluronic acid influences metabolic activity and osteogenic differentiation of periodontal ligament cells.Clinical oral investigations · 2023Article
- The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients.Gels (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA) is essential for the function of extracellular matrices in both hard and soft periodontal components. HA plays an important role in the mechanisms underlying inflammation and wound healing. HA is located in periodontal tissues in differing amounts, including non-mineralized tissues, such as gingiva and periodontal ligament, and lower levels located in mineralized tissues, such as cementum and alveolar bone. According to preliminary findings, HA exhibits potential in the regulation of periodontal tissue regeneration and in the treatment of periodontal disease. HA promotes symptomatic relief in both marginal gingiva and deeper periodontal tissues. The present review aimed to examine the role of HA in periodontal therapy, and investigate the current literature supporting its use in periodontal regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.