Evidence map›Paper›PMID 36278152›Full record

ArticleFrontiers in pharmacology2022

Identification of minimum essential therapeutic mixtures from cannabis plant extracts by screening in cell and animal models of Parkinson's disease.

Michael G Morash, Jessica Nixon, Lori M N Shimoda, Helen Turner, Alexander J Stokes, Andrea L Small-Howard, Lee D Ellis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Exploring Cannabinoid Effects Using Zebrafish (International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Zebrafish as an Animal Model in Cannabinoid Research.International journal of molecular sciences · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Michael G MorashNational Research Council of Canada, Halifax, NS, Canada.
Jessica NixonNational Research Council of Canada, Halifax, NS, Canada.
Lori M N ShimodaLaboratory of Immunology and Signal Transduction, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.
Helen TurnerLaboratory of Immunology and Signal Transduction, School of Natural Sciences and Mathematics, Chaminade University, Honolulu, HI, United States.
Alexander J StokesLaboratory of Experimental Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, United States.
Andrea L Small-HowardGBS Global Biopharma, Inc., Ottawa, ON, Canada.
Lee D EllisNational Research Council of Canada, Halifax, NS, Canada.
National Research Council Canada · CAChaminade University of Honolulu · USUniversity of Hawaiʻi at Mānoa · US

Funding

Cannabinoid and terpene regulation of nocioception and peripheral sensitization through ionotropic receptorsR15DA051749 · NIDA · CHAMINADE UNIVERSITY OF HONOLULU · PI TURNER, HELEN C · 2020 to 2020
$433k
NIDA NIH HHS R15 DA051749
6 · The paper itself

Abstract

Medicinal cannabis has shown promise for the symptomatic treatment of Parkinson's disease (PD), but patient exposure to whole plant mixtures may be undesirable due to concerns around safety, consistency, regulatory issues, and psychoactivity. Identification of a subset of components responsible for the potential therapeutic effects within cannabis represents a direct path forward for the generation of anti-PD drugs. Using an

Indexed as

cannabidiolcannabinoidscannabisdopaminemovement disorderneuroprotectionParkinson’s diseasezebrafish

Identifiers

PMID36278152
PMCPMC9586206
OpenAlexW4301594695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.