Evidence map›Paper›PMID 36278054›Full record

ArticleACS omega2022

Multifunctional Core@Satellite Magnetic Particles for Magnetoresistive Biosensors.

Raffaele Campanile, Adriano Acunzo, Emanuela Scardapane, Antonio Minopoli, Veronica C Martins, Rocco Di Girolamo, Susana Cardoso, Raffaele Velotta, Bartolomeo Della Ventura, Vincenzo Iannotti

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. FeMikrochimica acta · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Raffaele CampanileDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0002-0753-916X
Adriano AcunzoDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0003-3219-4623
Emanuela ScardapaneDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0003-3667-8166
Antonio MinopoliDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.
Veronica C MartinsINESC-Microsistemas e Nanotecnologias, Lisboa, Rua Alves Redol 9, 1000-049Lisbon, Portugal.
Rocco Di GirolamoDepartment of Chemistry, University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0001-8815-2997
Susana CardosoINESC-Microsistemas e Nanotecnologias, Lisboa, Rua Alves Redol 9, 1000-049Lisbon, Portugal.ORCID https://orcid.org/0000-0001-6913-6529
Raffaele VelottaDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0003-1077-8353
Bartolomeo Della VenturaDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0003-2920-6187
Vincenzo IannottiDepartment of Physics "E. Pancini", University of Naples Federico II, Via Cintia 26, 80126Naples, Italy.ORCID https://orcid.org/0000-0001-7229-5045
University of Naples Federico II · ITInstituto de Engenharia de Sistemas e Computadores Microsistemas e Nanotecnologias · PTSuperconducting and other Innovative Materials and Devices Institute · ITUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetoresistive (MR) biosensors combine distinctive features such as small size, low cost, good sensitivity, and propensity to be arrayed to perform multiplexed analysis. Magnetic nanoparticles (MNPs) are the ideal target for this platform, especially if modified not only to overcome their intrinsic tendency to aggregate and lack of stability but also to realize an interacting surface suitable for biofunctionalization without strongly losing their magnetic response. Here, we describe an MR biosensor in which commercial MNP clusters were coated with gold nanoparticles (AuNPs) and used to detect human IgG in water using an MR biochip that comprises six sensing regions, each one containing five U-shaped spin valve sensors. The isolated AuNPs (satellites) were stuck onto an aggregate of individual iron oxide crystals (core) so that the resulting core@satellite magnetic particles (CSMPs) could be functionalized by the photochemical immobilization technique-an easy procedure that leads to oriented antibodies immobilized upright onto gold. The morphological, optical, hydrodynamic, magnetic, and surface charge properties of CSMPs were compared with those exhibited by the commercial MNP clusters showing that the proposed coating procedure endows the MNP clusters with stability and ductility without being detrimental to magnetic properties. Eventually, the high-performance MR biosensor allowed us to detect human IgG in water with a detection limit of 13 pM (2 ng mL

Identifiers

PMID36278054
PMCPMC9583337
OpenAlexW4301368556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.