Evidence map›Paper›PMID 36278002›Full record

ArticleFrontiers in neuroscience2022

Retinal nerve fiber layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Bryan M Wong, Christopher Hudson, Emily Snook, Faryan Tayyari, Hyejung Jung, Malcolm A Binns, Saba Samet, Richard W Cheng, Carmen Balian, Efrem D Mandelcorn and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 1 country.

Bryan M WongFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Christopher HudsonDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Emily SnookFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Faryan TayyariSchool of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
Hyejung JungDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Malcolm A BinnsDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Saba SametDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Richard W ChengKensington Eye Institute, Toronto, ON, Canada.
Carmen BalianSchool of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
Efrem D MandelcornDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Edward MargolinDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Elizabeth FingerDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Sandra E BlackDepartment of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
David F Tang-WaiDepartment of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada.
Lorne ZinmanDepartment of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Brian TanRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Wendy LouDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Mario MasellisDepartment of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Agessandro AbrahaoDepartment of Medicine (Neurology), Sunnybrook Health Sciences Centre, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
Andrew FrankBruyere Research Institute, University of Ottawa, Ottawa, ON, Canada.
Derek BeatonRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Kelly M SunderlandRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Stephen R ArnottRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
ONDRI Investigators
Maria Carmela TartagliaDepartment of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada.
Wendy V HatchDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
University of Toronto · CABaycrest Hospital · CASunnybrook Health Science Centre · CAUniversity Health Network · CAUniversity of Waterloo · CAKensington Health · CAUniversity of Ottawa · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Tauopathy and transactive response DNA binding protein 43 (TDP-43) proteinopathy are associated with neurodegenerative diseases. These proteinopathies are difficult to detect Study design: Prospective, multi-centre, observational study. Materials and methods: pRNFL and macular SD-OCT images were acquired in both eyes of each participant using Heidelberg Spectralis SD-OCT. Global and pRNFL thickness in 6 sectors were analyzed, as well as macular thickness in a central 1 mm diameter zone and 4 surrounding sectors. Linear mixed model methods adjusting for baseline differences between groups were used to compare the two groups with respect to pRNFL and macular thickness. Results: A significant difference was found in mean pRNFL thickness between groups, with the TDP-43 group ( Conclusion: The finding that the temporal pRNFL in the TDP-43 group was on average 15.46 μm thinner could potentially have clinical significance. Future work with larger sample sizes, longitudinal studies, and at the level of retinal sublayers will help to determine the utility of SD-OCT to differentiate between these two proteinopathies.

Indexed as

amyotrophic lateral sclerosisfrontotemporal lobar degenerationoptical coherence tomographyretinal nerve fibre layertauopathyTDP-43 proteinopathy

Identifiers

PMID36278002
PMCPMC9583385
OpenAlexW4303411577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.