Evidence map›Paper›PMID 36277880›Full record

SynthesisBioMed research international2022

Meta-Analysis of Matrix Metalloproteinases in the Risk of Cardiovascular and Neurodegenerative Diseases.

Ruizhen Huang, XinYang, Rui Zhu, Junkun Song, Mei Luo, Di-Ang Chen

RetractedOpen access · hybridAbstract readMeta-AnalysisRetracted Publication
In one paragraph

Synthesis in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ruizhen HuangDepartment of Cardiovascular, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
XinYangDepartment of Breast Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
Rui ZhuDepartment of Orthopedics, Nanjing University of Chinese Medicine, Jiangsu 210023, China.
Junkun SongDepartment of Cardiovascular, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
Mei LuoDepartment of Hospital Infection Management, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.ORCID https://orcid.org/0000-0003-1084-2378
Di-Ang ChenDepartment of Andrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.ORCID https://orcid.org/0000-0001-9844-8046
Chengdu University of Traditional Chinese Medicine · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the risk of cardiovascular and neurodegenerative diseases induced by matrix metalloproteinases (MMPs) by meta-analysis. Methods: Relevant literature was searched from Wanfang Medical Center, CNQI, VIP, PubMed, and other domestic and foreign literature databases for the research direction, and the risk of cardiovascular and neurodegenerative diseases induced by MMPs was meta-analyzed using the fixed-effect model and random-effect model. Results: MMP-1 and MMP-9 were risk factors for cardiovascular diseases by fixed and random-effect model analysis, respectively, while MMP-2 and MMP-9 were risk factors for increased neurodegenerative diseases by random-effect model analysis. Conclusion: MMP-1 and MMP-9 are risk factors for cardiovascular diseases, and MMP-2 and MMP-9 are major factors for increased risk of neurodegenerative diseases. MMP-1, MMP-2, and MMP-9 can be used as new targets for clinical diagnosis, treatment, and research of subsequent cardiovascular and neurodegenerative diseases.

Indexed as

Cardiovascular DiseasesNeurodegenerative DiseasesHumansMatrix Metalloproteinase 1Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix MetalloproteinasesMatrix Metalloproteinase 1Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinases

Identifiers

PMID36277880
PMCPMC9584685
OpenAlexW4305081956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.