ArticleFrontiers in cardiovascular medicine2022
The impact of coronary microvascular dysfunction on the discordance between fractional flow reserve and resting full-cycle ratio in patients with chronic coronary syndromes.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 17 citations in OpenAlex.
- Validation of angiography-based FFR in non-culprit vessels of patients presenting with STEMI.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Obstructive Sleep Apnea in Patients with Significant Coronary Artery Disease: An Underdiagnosed Condition.Journal of clinical medicine · 2026Article
- Prevalence of heart failure with preserved ejection fraction in patients with ischemia and non-obstructive coronary arteries.Scientific reports · 2026Article
- Increased dose of adenosine and the relationship between the resting full-cycle ratio and fractional flow reserve.International journal of cardiology. Heart & vasculature · 2025Article
- Interpretation of Discordance Between Non-Hyperemic Pressure Ratios and Fractional Flow Reserve: Potential Mechanisms and Clinical Implications.Reviews in cardiovascular medicine · 2025Review
- Remote assessment of coronary stenosis - a valid alternative to invasive testing for non-culprit lesions?Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Tailored treatment of specific diagnosis improves symptoms and quality of life in patients with myocardial Ischemia and Non-obstructive Coronary Arteries.Scientific reports · 2025Article
- The role of aortic valve area in the quantitative flow ratio-fractional flow reserve discrepancy in patients with coronary artery disease and severe aortic stenosis.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Diagnostic performance of multi-branch coronary angiography-based index of microcirculatory resistance: a novel approach.Frontiers in medicine · 2025Article
- Implementation of Microcirculation Examination in Clinical Practice-Insights from the Nationwide POL-MKW Registry.Medicina (Kaunas, Lithuania) · 2024Article
- The change of angina levels in patients with chronic coronary syndromes and coronary microcirculatory dysfunction - a prospective study with 24 months follow-up.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Resting full-cycle ratio (RFR) is an alternative to fractional flow reserve (FFR) for the evaluation of borderline coronary artery lesions. Although FFR and RFR results are discordant in some cases, factors associated with the discordance remain unclear. The role of coronary microvascular dysfunction (CMD) is discussed as a potential mechanism to explain these discrepancies. Aim: The study aimed to assess concordance between RFR and FFR in a real-life cohort from a high-volume center regarding the role of CMD. Methods: Consecutive patients with borderline coronary lesions undergoing coronary functional testing for chronic coronary syndromes were included in the study. Measurements of RFR and FFR were performed alongside additional coronary flow reserve (CFR), resistance reserve ratio (RRR), and an index of microcirculatory resistance (IMR) measurements. CMD was defined according to the current guideline by either IMR ≥25 or CFR ≤2.0 in vessels with no significant stenosis. Results: Measurements were performed in 157 coronary arteries, in 101 patients, with a median age of 66 y., 74% male, with prior history of arterial hypertension (96%), dyslipidaemia (91%), and diabetes (40%). The median value of vessel diameter stenosis was 45% according to QCA.Overall, FFR and RFR values were significantly correlated ( Conclusion: In discrepant RFR/FFR vessels, CMD is more prevalent than in concordant RFR/FFR measurements, which can be driven by lower CFR or RRR values. Further research is needed to confirm this observation.
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