ArticleFrontiers in endocrinology2022
Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute pancreatitis.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Immune-Enhancing Treatment among Acute Necrotizing Pancreatitis Patients with Metabolic Abnormalities: AGut and liver · 2024Trial
- Hypertriglyceridaemia-Associated Acute Pancreatitis: Pathophysiological Insights and Advances in Clinical Management.Biomedicines · 2026Review
- Prognostic Value of Stress-Induced Hyperglycemia in High-Acuity Emergency Department Patients.Journal of clinical medicine · 2026Article
- Differences in clinical features and prognosis between hypertriglyceridemia and other causes of acute pancreatitis: a dual perspective based on metabolic disorders and inflammatory response.Frontiers in endocrinology · 2026Article
- Admission hyperglycemia increases risk of UTI in acute pancreatitis: a dose-response and PSM-based analysis.European journal of medical research · 2025Article
- The association between serum HbA1c and infected pancreatic necrosis in acute necrotizing pancreatitis.BMC gastroenterology · 2025Article
- The Stress Hyperglycemia Ratio as a Predictor of Clinical Outcomes in Acute Pancreatitis: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Stress-Induced Hyperglycemia as an Independent Predictor of Infectious Pancreatic Necrosis in Acute Pancreatitis: A Machine Learning-Driven Prognostic Model.Journal of inflammation research · 2025Article
- The Interaction and Implication of Stress-Induced Hyperglycemia and Cytokine Release Following Traumatic Injury: A Structured Scoping Review.Diagnostics (Basel, Switzerland) · 2024Article
- Correlation of hyperglycemia and balthazar classification in patients with acute pancreatitis.Pakistan journal of medical sciences · 2024Article
- Early clinical predictors of infected pancreatic necrosis: a multicentre cohort study.eGastroenterology · 2024Article
- Impact of admission glucose and 30-day major adverse cardiovascular events on patients with chest pain in an emergency setting: insights from the China EMPACT registry.Frontiers in cardiovascular medicine · 2024Article
- Admission blood glucose and 30-day mortality in patients with acute decompensated heart failure: prognostic significance in individuals with and without diabetes.Frontiers in endocrinology · 2024Article
- Incidence and risk factors of fasting hyperglycaemia following first-attack acute pancreatitis before discharge: a retrospective study.BMC gastroenterology · 2023Article
- Acute Pancreatitis as an Unusual Culprit of Diabetic Ketoacidosis in a Nondiabetic: A Case-Based Review.Case reports in endocrinology · 2023Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To determine the impact of glucose levels at admission and during first week (early phase) on clinical outcomes in patients with acute pancreatitis (AP) and to investigate the relationship between stress hyperglycaemia (SHG) and hypertriglyceridaemia (HTG). Methods: Two independent and prospective databases were retrospectively analysed (n = 1792). Patients admitted with pain of less than 48 hours and confirmed AP were included. SHG was defined as admission blood glucose ≥ 10.00 mmol/L (non-diabetic) or ≥ 16.67 mmol/L (diabetic). Blood glucose records for the first week were inspected to determine whether SHG lasted ≥ 48 hours (persistent) or < 48 hours (transient). Clinical outcomes were compared between designated patient groups using multivariate and trend analyses. The correlation between SHG and HTG (serum triglyceride ≥ 5.65 mmol/L) was also analysed. Results: On admission, SHG was present in 27.8% (499/1792) patients; during the first 48 hours of admission, transient and persistent SHG was found in 31% (556/1792) and 8.0% (144/1792) patients, respectively. Admission SHG was associated with higher incidence of persistent organ failure, acute necrotic collection, major infection, and mortality as well as prolonged length of hospital stay (all Conclusions: Admission and persistent SHG during the first week of admission worsens clinical outcomes of AP patients. These effects are more pronounced when admission HTG co-existed.
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