Evidence map›Paper›PMID 36277682›Full record

ArticleIOP SciNotes2022

Prediction of malignant transformation in oral epithelial dysplasia using machine learning.

James Ingham, Caroline I Smith, Barnaby G Ellis, Conor A Whitley, Asterios Triantafyllou, Philip J Gunning, Steve D Barrett, Peter Gardener, Richard J Shaw, Janet M Risk and 1 more

Abstract read
In one paragraph

Article in IOP SciNotes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

James InghamDepartment of Physics, University of Liverpool, L69 7ZE, United Kingdom.
Caroline I SmithDepartment of Physics, University of Liverpool, L69 7ZE, United Kingdom.ORCID https://orcid.org/0000-0001-6878-0697
Barnaby G EllisDepartment of Physics, University of Liverpool, L69 7ZE, United Kingdom.
Conor A WhitleyDepartment of Physics, University of Liverpool, L69 7ZE, United Kingdom.
Asterios TriantafyllouDepartment of Pathology, Liverpool Clinical Laboratories, University of Liverpool, L69 3GA, United Kingdom.
Philip J GunningDepartment of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L3 9TA, United Kingdom.
Steve D BarrettDepartment of Physics, University of Liverpool, L69 7ZE, United Kingdom.
Peter GardenerManchester Institute of Biotechnology, University of Manchester, M1 7DN, United Kingdom.
Richard J ShawDepartment of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L3 9TA, United Kingdom.
Janet M RiskDepartment of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, L3 9TA, United Kingdom.
Peter WeightmanDepartment of Physics, University of Liverpool, L69 7ZE, United Kingdom.ORCID https://orcid.org/0000-0002-0907-3930

Funding

Cancer Research UK 26196
6 · The paper itself

Abstract

A machine learning algorithm (MLA) has been applied to a Fourier transform infrared spectroscopy (FTIR) dataset previously analysed with a principal component analysis (PCA) linear discriminant analysis (LDA) model. This comparison has confirmed the robustness of FTIR as a prognostic tool for oral epithelial dysplasia (OED). The MLA is able to predict malignancy with a sensitivity of 84 ± 3% and a specificity of 79 ± 3%. It provides key wavenumbers that will be important for the development of devices that can be used for improved prognosis of OED.

Indexed as

FTIR spectroscopymachine learningOEDoral cancer

Identifiers

PMID36277682
PMCPMC9580266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.