Evidence map›Paper›PMID 36277654›Full record

ArticleChemical science2022

Topologically switchable and gated transcription machinery.

Pu Zhang, Amit Fischer, Yu Ouyang, Yang Sung Sohn, Rachel Nechushtai, Junji Zhang, He Tian, Chunhai Fan, Itamar Willner

Abstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Dynamic Transcription Machineries in Protocells.Journal of the American Chemical Society · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pu ZhangInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem Jerusalem 91904 Israel itamar.willner@mail.huji.ac.il.
Amit FischerInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem Jerusalem 91904 Israel itamar.willner@mail.huji.ac.il.ORCID https://orcid.org/0000-0003-0576-2197
Yu OuyangInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem Jerusalem 91904 Israel itamar.willner@mail.huji.ac.il.
Yang Sung SohnInstitute of Life Science, The Hebrew University of Jerusalem Jerusalem 91904 Israel.
Rachel NechushtaiInstitute of Life Science, The Hebrew University of Jerusalem Jerusalem 91904 Israel.
Junji ZhangKey Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology Shanghai China.ORCID https://orcid.org/0000-0003-2823-4637
He TianKey Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science and Technology Shanghai China.ORCID https://orcid.org/0000-0003-3547-7485
Chunhai FanSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, National Center for Translational Medicine, Shanghai Jiao Tong University 200240 Shanghai China.ORCID https://orcid.org/0000-0002-7171-7338
Itamar WillnerInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem Jerusalem 91904 Israel itamar.willner@mail.huji.ac.il.ORCID https://orcid.org/0000-0001-9710-9077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Topological barriers control in nature the transcription machinery, thereby perturbing gene expression. Here we introduce synthetically designed DNA templates that include built-in topological barriers for switchable, triggered-controlled transcription of RNA aptamers. This is exemplified with the design of transcription templates that include reversible and switchable topological barriers consisting of a Sr

Identifiers

PMID36277654
PMCPMC9473513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.