Evidence map›Paper›PMID 36277615›Full record

ArticleFrontiers in allergy2022

Spi-B alleviates food allergy by securing mucosal barrier and immune tolerance in the intestine.

Narumi Ishihara, Yutaka Nakamura, Kyosuke Yakabe, Seiga Komiyama, Yumiko Fujimura, Tsuneyasu Kaisho, Shunsuke Kimura, Koji Hase

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Narumi IshiharaDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Yutaka NakamuraDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Kyosuke YakabeDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Seiga KomiyamaDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Yumiko FujimuraDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Tsuneyasu KaishoDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.
Shunsuke KimuraDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Koji HaseDivision of Biochemistry, Faculty of Pharmacy, School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Keio University · JPJapan Science and Technology Agency · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food allergy is a type I allergic reaction induced by mast cells and is mainly activated by allergen-specific immunoglobulin (Ig)E. Spi-B is an E26-transformation-specific (Ets) family transcription factor essential for the differentiation and functional maturation of several immune cell subsets, including mast cells. However, the possible involvement of Spi-B in food allergy remains unclear. In this study, we found that Spi-B-deficient mice were highly susceptible to food allergy to ovalbumin (OVA), as indicated by the exacerbation of diarrhea and elevation of serum IgE levels. These pathological changes were associated with enhanced mast cell infiltration into the intestinal lamina propria. Activation of mast cells in the intestinal mucosa was observed in

Indexed as

epithelial barrierfood allergyIgEoral toleranceSpi-B

Identifiers

PMID36277615
PMCPMC9584830
OpenAlexW4302304564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.