Evidence map›Paper›PMID 36277232›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis.

Estelle Seyman, David Kim, Aditya Bharatha, Courtney Casserly, Kristen Krysko, Roy-Hewitson Chantal, Paula Alcaide-Leon, Suradech Suthiphosuwan, Jiwon Oh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Urogenital dysfunction in neurological diseases.Nature reviews. Neurology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Estelle SeymanDivision of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
David KimDepartment of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.
Aditya BharathaDivision of Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, London, Ontario, Canada.
Courtney CasserlyDepartment of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.
Kristen KryskoDivision of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-0090-597X
Roy-Hewitson ChantalDivision of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Paula Alcaide-LeonDivision of Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, London, Ontario, Canada.
Suradech SuthiphosuwanDivision of Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, London, Ontario, Canada.
Jiwon OhDivision of Neurology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-5519-6088
St. Michael's Hospital · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sexual dysfunction (SD) is frequently reported in multiple sclerosis (MS) and is likely related to MS-related damage to the spinal cord (SC). Objective: To assess associations between SD and quantitative MRI measures in people with MS (pwMS). Methods: This pilot study included 17 pwMS with SD who completed questionnaires assessing SD, mood, and fatigue. All participants underwent brain, cervical, and thoracic SC-MRI at 3T. Quantitative brain and SC-MRI measures, including brain/SC atrophy, SC lesion count, diffusion-tensor imaging (DTI) indices (fractional anisotropy [FA], mean, perpendicular, parallel diffusivity [MD, λ Results: Subjects were a mean age of 46.9 years and 29% female. All subjects had self-reported SD (MSISQ-19 = 40.7, SQoL: 55.9) and 65% had a concurrent psychiatric diagnosis. When correlations between SD severity were assessed with individual brain and SC-MRI measures while controlling for psychiatric symptomatology, no associations were found. The only variables showing independent associations with SD were anxiety ( Conclusion: We found no correlations between quantitative MRI measures in the brain and SC and severity of SD in pwMS, but psychiatric symptomatology and fatigue severity demonstrated relationships with SD. The multifactorial nature of SD in pwMS mandates a multidisciplinary approach.

Indexed as

multiple sclerosisquality of lifequantitative MRIsexual dysfunctionspinal cord

Identifiers

PMID36277232
PMCPMC9585573
OpenAlexW4306954832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.