Evidence map›Paper›PMID 36276935›Full record

ArticleFrontiers in genetics2022

Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage.

Jing Chen, Renhua Li, Sarah Knapp, Guizhi Zhu, Robert L Whitener, Edward H Leiter, Clayton E Mathews

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jing ChenDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Renhua LiHenry M Jackson Foundation for the Advancement of Military Medicine (HJF), Bethesda, MD, United States.
Sarah KnappDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Guizhi ZhuDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Robert L WhitenerDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
Edward H LeiterThe Jackson Laboratory, Bar Harbor, ME, United States.
Clayton E MathewsDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, United States.
University of Florida · USHenry M. Jackson Foundation · USJackson Laboratory · US

Funding

GENETICS &PATHOGENESIS OF NON-OBESE DIABETIC (NOD) MICER01DK036175 · NIDDK · JACKSON LABORATORY · PI LEITER, EDWARD H · 1986 to 2005
$2.1M
NIDDK NIH HHS R01 DK036175
6 · The paper itself

Abstract

Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell susceptibility or resistance to AL-induced diabetes on Chromosomes (Chr) 2, 3, 8, and a single nucleotide polymorphism in

Indexed as

alloxanbeta cell (β cell)diabetesepistasisfree radicalmitochondrial genomemouse model

Identifiers

PMID36276935
PMCPMC9585181
OpenAlexW4303021924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.