Evidence map›Paper›PMID 36276649›Full record

ArticleTheranostics2022

A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies.

Joanna M Wasielewska, Juliana C S Chaves, Rebecca L Johnston, Laura A Milton, Damián Hernández, Liyu Chen, Jae Song, Wendy Lee, Gerhard Leinenga, Rebecca M Nisbet and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Differential Cytokine Responses of APOE3 and APOE4 Blood-brain Barrier Cell Types to SARS-CoV-2 Spike Proteins.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Joanna M WasielewskaCell & Molecular Biology Department, Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute; Brisbane, QLD, Australia.
Juliana C S ChavesCell & Molecular Biology Department, Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute; Brisbane, QLD, Australia.
Rebecca L JohnstonGenetics & Computational Biology Department, QIMR Berghofer Medical Research Institute; Brisbane, QLD, Australia.
Laura A MiltonCell & Molecular Biology Department, Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute; Brisbane, QLD, Australia.
Damián HernándezDepartment of Anatomy and Physiology, The University of Melbourne; Parkville, VIC, Australia.
Liyu ChenClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland; Brisbane, QLD, Australia.
Jae SongClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland; Brisbane, QLD, Australia.
Wendy LeeClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland; Brisbane, QLD, Australia.
Gerhard LeinengaClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland; Brisbane, QLD, Australia.
Rebecca M NisbetThe Florey Institute of Neuroscience and Mental Health; Parkville, VIC, Australia.
Alice PébayDepartment of Anatomy and Physiology, The University of Melbourne; Parkville, VIC, Australia.
Jürgen GötzClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland; Brisbane, QLD, Australia.
Anthony R WhiteCell & Molecular Biology Department, Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute; Brisbane, QLD, Australia.
Lotta E OikariCell & Molecular Biology Department, Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute; Brisbane, QLD, Australia.
University of Queensland · AUUniversity of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAntibodies, Monoclonal, HumanizedBlood-Brain BarrierApolipoprotein E3Apolipoprotein E4BrainDrug Delivery SystemsHumansHydrogelsMicrobubblesaducanumabAntibodies, Monoclonal, HumanizedApolipoprotein E3Apolipoprotein E4HydrogelsAduhelmAlzheimer's diseaseblood-brain barrierdrug deliveryfocused ultrasound

Identifiers

PMID36276649
PMCPMC9576609
OpenAlexW4307429836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.