Evidence map›Paper›PMID 36276587›Full record

ArticlePNAS nexus2022

Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice.

Stephen Chang, John Tat, Shyamsundar Pal China, Hema Kalyanaraman, Shunhui Zhuang, Adriano Chan, Cassandra Lai, Zoran Radic, Engy A Abdel-Rahman, Darren E Casteel and 3 more

Open access · goldAbstract read
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cyanide overproduction impairs cellular bioenergetics in Down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. The vitamin BClinical toxicology (Philadelphia, Pa.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Stephen ChangDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
John TatDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Shyamsundar Pal ChinaDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-0062-3593
Hema KalyanaramanDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Shunhui ZhuangDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Adriano ChanDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Cassandra LaiDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Zoran RadicSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-0806-3869
Engy A Abdel-RahmanTumor Biology Research Program, Children's Cancer Hospital, Cairo 57357, Egypt.
Darren E CasteelDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Renate B PilzDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Sameh S AliTumor Biology Research Program, Children's Cancer Hospital, Cairo 57357, Egypt.ORCID https://orcid.org/0000-0002-0339-6106
Gerry R BossDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0002-9758-8714
University of California San Diego · USChildren Cancer Hospital · EG

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Mechanisms of vascular pathology from abnormal protein kinase G signalingR01HL132141 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PILZ, RENATE B · 2016 to 2025
$4.5M
PKG Regulation of Sirtuin 1 as a Novel Treatment Strategy for Age-related OsteoporosisR01AG070778 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PILZ, RENATE B · 2021 to 2025
$2.3M
Targeting defective NO/cGMP signaling as novel therapy for diabetic osteoporosisR01AR068601 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PILZ, RENATE B · 2016 to 2020
$1.8M
NHLBI NIH HHS R01 HL132141NIAMS NIH HHS R01 AR068601NIA NIH HHS R01 AG070778NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Increased oxidative stress underlies a variety of diseases, including diabetes. Here, we show that the cobalamin/vitamin B

Indexed as

antioxidantcobinamidediabetesoxidative stress

Identifiers

PMID36276587
PMCPMC9578022
OpenAlexW4295681852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.