Evidence map›Paper›PMID 36276179›Full record

ArticleFrontiers in synaptic neuroscience2022

Protein phosphatase-1 inhibitor-2 promotes PP1

Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Makaía M Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M MacLean and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in synaptic neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Regulation of PP1 interaction with I-2, neurabin, and F-actin.Molecular and cellular neurosciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Karl FoleyDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Haider AltimimiDepartment of Neurology and Neurosurgery, Center for Research in Neuroscience, McGill University, Montreal, QC, Canada.
Hailong HouDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Yu ZhangDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Cody McKeeDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Makaía M Papasergi-ScottDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Hongtian YangDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Abigail MayerNeuroscience Graduate Program, Department of Neuroscience, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, United States.
Nancy WardDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
David M MacLeanDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
Angus C NairnDepartment of Psychiatry, Yale University, New Haven, CT, United States.
David StellwagenDepartment of Neurology and Neurosurgery, Center for Research in Neuroscience, McGill University, Montreal, QC, Canada.
Houhui XiaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United States.
University of Rochester Medical Center · USMcGill University · CAYale University · US

Funding

Acid-Sensing Ion Channel gating: Conformations and ConsequencesR35GM137951 · NIGMS · UNIVERSITY OF ROCHESTER · PI David Malcolm MacLean · 2020 to 2026
$2.8M
Protein phosphatase 1 isoforms and human de novo mutations in synaptic plasticityF30MH122046 · NIMH · UNIVERSITY OF ROCHESTER · PI FOLEY, KARL FRANCIS WILSON · 2020 to 2023
$205k
NIGMS NIH HHS R35 GM137951NIMH NIH HHS F30 MH122046
6 · The paper itself

Abstract

Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1

Indexed as

FRET-Förster resonance energy transferhippocampusinhibitor-2protein phosphatase-1regulatory subunitscaffolding proteinsynaptic transmission

Identifiers

PMID36276179
PMCPMC9582336
OpenAlexW4302303741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.