ArticleFrontiers in oncology2022
Symptoms and experiences of frailty in lung cancer patients with chemotherapy: A mixed-method approach.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06448455 (Observation of Frailty in Lung Cancer Patients and Its Influencing Factors), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observation of Frailty in Lung Cancer Patients and Its Influencing Factors
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Prevalence of Frailty and Its Predictors Among Patients With Cancer at the Chemotherapy Stage: Systematic Review.JMIR cancer · 2025Pooled it
- Relationship between quality of life before treatment and survival in patients with hematological malignancies: A meta-analysis.Fukushima journal of medical science · 2025Pooled it
- Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.Frontiers in oncology · 2025Pooled it
- Systematic review of associations between anxiety, depression, and functional/biological aging among cancer survivors.JNCI cancer spectrum · 2024Pooled it
- Associations of frailty with symptoms, and HRQOL in older cancer survivors after cancer treatments: a systematic review and meta-analyses.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Sequential chemo-durvalumab, reduced-dose RT, and consolidation durvalumab for unresectable stage III NSCLC unfit for PACIFIC regimen (DEDALUS trial).JNCI cancer spectrum · 2026Trial
- Latent classes of frailty and their association with intrinsic capacity inolder cancer survivors: A study under the healthy aging paradigm.Global health & medicine · 2026Article
- Review
- Causal relationship between branched-chain amino acids and their metabolites and frailty: A two-sample Mendelian randomization study.Medicine · 2025Article
- Constructing and evaluating a predictive model for the risk of preoperative frailty in breast cancer patients.BMC women's health · 2025Article
- Prevalence and impact of frailty on unplanned hospitalizations among adult patients with cancer in Taiwan.The oncologist · 2025Article
- The relationship between frailty and depression in Chinese elderly prostate cancer patients following radical surgery: the mediating effect of sleep disturbances.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Quality of Life and Factors Associated with Quality of Life among Patients with Lung Cancer in Northeastern Thailand.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Heterogeneity of pain-fatigue-sleep disturbance symptom clusters in lung cancer patients after chemotherapy: a latent profile analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Anxiety and Depression in Advanced and Metastatic Lung Cancer Patients-Correlations with Performance Status and Type of Treatment.Medicina (Kaunas, Lithuania) · 2024Article
- Therapy-Related Symptoms and Sense of Coherence: The Mediating Role of Social Support and Hope in Lung Cancer Patients Undergoing Chemotherapy.Patient preference and adherence · 2024Article
- How social support influences learned helplessness in lung cancer patients: the chain mediation role of individual resilience and self-efficacy.Frontiers in psychology · 2024Article
- Article
- Heterogeneity of vulnerability and taste changes in older cancer patients undergoing chemotherapy: a latent class analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study was to explore the symptoms and experiences of frailty in lung cancer patients treated with chemotherapy. Methods: Quantitative and qualitative research methods were implemented. A total of 302 patients aged > 18 years were recruited by convenience sampling method. Quantitative data were collected through the General Demographic Characteristics questionnaire, the Frailty Phenotype scale, the Cancer Fatigue Scale, the Hospital Anxiety and Depression Scale and the Pittsburgh Sleep Quality Index. Fourteen patients with a score of Frailty Phenotype scale ≥ 3 were drawn and their interviews were thematically analyzed. Results: The mean Frailty Phenotype score was (1.63±1.35), suggesting that most of the patients were in pre-frailty conditions. A total of 64 (21.2%) patients were non-frail, 168 (55.6%) patients were pre-frail, 70 (23.2%) patients were frail. The mean CFS, HADS scores, and PSQI scores were (26.86±8.93), (15.42±9.73), and (6.18±4.39), respectively. The Number of chemotherapy times was positively associated with frailty. Anxiety fatigue, depression and poor sleep quality positively correlated with frailty. The qualitative research showed four themes. Theme 1: the most reported symptoms of frailty were physical symptoms and psychological symptoms. Physical symptoms included fatigue, low physical activity, weight loss and poor sleep quality. Psychological symptoms included anxiety, depression and low social activities. Theme 2: frailty was mainly related to lung cancer and chemotherapeutic drugs, which can cause decreased appetite, constipation and altered taste. Theme 3: patients used bad coping strategies to manage the symptoms of frailty. Theme 4: the social support of patients was weak, especially regarding emotional support. Conclusion: The most frequent symptoms reported by lung cancer patients treated with chemotherapy were anxiety, fatigue, depression, low physical activity and poor sleep quality. Patients also complained of bad coping strategies and weak support. Medical staff should strengthen the management of frailty, aiming at improving the quality of life in lung cancer patients treated with chemotherapy.
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